MicroRNAs in mouse development and disease

MicroRNAs, small non-coding RNAs which act as repressors of target genes, were discovered in 1993, and since then have been shown to play important roles in the development of numerous systems. Consistent with this role, they are also implicated in the pathogenesis of multiple diseases. Here we revi...

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Detalles Bibliográficos
Autores principales: Lewis, Morag A., Steel, Karen P.
Formato: Texto
Lenguaje:English
Publicado: Academic Press 2010
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2938480/
https://www.ncbi.nlm.nih.gov/pubmed/20152923
http://dx.doi.org/10.1016/j.semcdb.2010.02.004
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author Lewis, Morag A.
Steel, Karen P.
author_facet Lewis, Morag A.
Steel, Karen P.
author_sort Lewis, Morag A.
collection PubMed
description MicroRNAs, small non-coding RNAs which act as repressors of target genes, were discovered in 1993, and since then have been shown to play important roles in the development of numerous systems. Consistent with this role, they are also implicated in the pathogenesis of multiple diseases. Here we review the involvement of microRNAs in mouse development and disease, with particular reference to deafness as an example.
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spelling pubmed-29384802010-10-13 MicroRNAs in mouse development and disease Lewis, Morag A. Steel, Karen P. Semin Cell Dev Biol Review MicroRNAs, small non-coding RNAs which act as repressors of target genes, were discovered in 1993, and since then have been shown to play important roles in the development of numerous systems. Consistent with this role, they are also implicated in the pathogenesis of multiple diseases. Here we review the involvement of microRNAs in mouse development and disease, with particular reference to deafness as an example. Academic Press 2010-09 /pmc/articles/PMC2938480/ /pubmed/20152923 http://dx.doi.org/10.1016/j.semcdb.2010.02.004 Text en © 2010 Elsevier Ltd. https://creativecommons.org/licenses/by/3.0/ Open Access under CC BY 3.0 (https://creativecommons.org/licenses/by/3.0/) license
spellingShingle Review
Lewis, Morag A.
Steel, Karen P.
MicroRNAs in mouse development and disease
title MicroRNAs in mouse development and disease
title_full MicroRNAs in mouse development and disease
title_fullStr MicroRNAs in mouse development and disease
title_full_unstemmed MicroRNAs in mouse development and disease
title_short MicroRNAs in mouse development and disease
title_sort micrornas in mouse development and disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2938480/
https://www.ncbi.nlm.nih.gov/pubmed/20152923
http://dx.doi.org/10.1016/j.semcdb.2010.02.004
work_keys_str_mv AT lewismoraga micrornasinmousedevelopmentanddisease
AT steelkarenp micrornasinmousedevelopmentanddisease

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