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High Resolution Mapping of Protein Sequence–Function Relationships
We present a large-scale approach to investigate the functional consequences of sequence variation in a protein. The approach entails the display of hundreds of thousands of protein variants, moderate selection for activity, and high throughput DNA sequencing to quantify the performance of each vari...
| Autores principales: | , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2938879/ https://www.ncbi.nlm.nih.gov/pubmed/20711194 http://dx.doi.org/10.1038/nmeth.1492 |