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In Vitro and In Vivo Studies of the Trypanocidal Properties of WRR-483 against Trypanosoma cruzi

BACKGROUND: Cruzain, the major cysteine protease of Trypanosoma cruzi, is an essential enzyme for the parasite life cycle and has been validated as a viable target to treat Chagas' disease. As a proof-of-concept, K11777, a potent inhibitor of cruzain, was found to effectively eliminate T. cruzi...

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Detalles Bibliográficos
Autores principales:	Chen, Yen Ting, Brinen, Linda S., Kerr, Iain D., Hansell, Elizabeth, Doyle, Patricia S., McKerrow, James H., Roush, William R.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2939063/ https://www.ncbi.nlm.nih.gov/pubmed/20856868 http://dx.doi.org/10.1371/journal.pntd.0000825

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