Nephrocystin-1 Forms a Complex with Polycystin-1 via a Polyproline Motif/SH3 Domain Interaction and Regulates the Apoptotic Response in Mammals

Mutations in PKD1, the gene encoding for the receptor Polycystin-1 (PC-1), cause autosomal dominant polycystic kidney disease (ADPKD). The cytoplasmic C-terminus of PC-1 contains a coiled-coil domain that mediates an interaction with the PKD2 gene product, Polycystin-2 (PC-2). Here we identify a nov...

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Detalles Bibliográficos
Autores principales: Wodarczyk, Claas, Distefano, Gianfranco, Rowe, Isaline, Gaetani, Massimiliano, Bricoli, Barbara, Muorah, Mordi, Spitaleri, Andrea, Mannella, Valeria, Ricchiuto, Piero, Pema, Monika, Castelli, Maddalena, Casanova, Ariel E., Mollica, Luca, Banzi, Manuela, Boca, Manila, Antignac, Corinne, Saunier, Sophie, Musco, Giovanna, Boletta, Alessandra
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2939065/
https://www.ncbi.nlm.nih.gov/pubmed/20856870
http://dx.doi.org/10.1371/journal.pone.0012719

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