Multiple enhancers located in a 1-Mb region upstream of POU3F4 promote expression during inner ear development and may be required for hearing

POU3F4 encodes a POU-domain transcription factor required for inner ear development. Defects in POU3F4 function are associated with X-linked deafness type 3 (DFN3). Multiple deletions affecting up to ~900-kb upstream of POU3F4 are found in DFN3 patients, suggesting the presence of essential POU3F4 e...

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Detalles Bibliográficos
Autores principales: Naranjo, Silvia, Voesenek, Krysta, de la Calle-Mustienes, Elisa, Robert-Moreno, Alex, Kokotas, Haris, Grigoriadou, Maria, Economides, John, Van Camp, Guy, Hilgert, Nele, Moreno, Felipe, Alsina, Berta, Petersen, Michael B., Kremer, Hannie, Gómez-Skarmeta, José Luis
Formato: Texto
Lenguaje:English
Publicado: Springer-Verlag 2010
Materias:
Original Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2939330/
https://www.ncbi.nlm.nih.gov/pubmed/20668882
http://dx.doi.org/10.1007/s00439-010-0864-x

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