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Allele-specific recognition of the 3′ splice site of INS intron 1

Genetic predisposition to type 1 diabetes (T1D) has been associated with a chromosome 11 locus centered on the proinsulin gene (INS) and with differential steady-state levels of INS RNA from T1D-predisposing and -protective haplotypes. Here, we show that the haplotype-specific expression is determin...

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Detalles Bibliográficos
Autores principales: Kralovicova, Jana, Vorechovsky, Igor
Formato: Texto
Lenguaje:English
Publicado: Springer-Verlag 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2939332/
https://www.ncbi.nlm.nih.gov/pubmed/20628762
http://dx.doi.org/10.1007/s00439-010-0860-1