Mass Spectrometric Analysis of Intact Human Monoclonal Antibody Aggregates Fractionated by Size-Exclusion Chromatography

PURPOSE: The aim of this study was to develop a method to characterize intact soluble monoclonal IgG1 antibody (IgG) oligomers by mass spectrometry. METHODS: IgG aggregates (dimers, trimers, tetramers and high-molecular-weight oligomers) were created by subjecting an IgG formulation to several pH ju...

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Detalles Bibliográficos
Autores principales: Kükrer, Başak, Filipe, Vasco, van Duijn, Esther, Kasper, Piotr T., Vreeken, Rob J., Heck, Albert J. R., Jiskoot, Wim
Formato: Texto
Lenguaje:English
Publicado: Springer US 2010
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2939344/
https://www.ncbi.nlm.nih.gov/pubmed/20680668
http://dx.doi.org/10.1007/s11095-010-0224-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2939344/
https://www.ncbi.nlm.nih.gov/pubmed/20680668
http://dx.doi.org/10.1007/s11095-010-0224-5

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