Pathological Hallmarks, Clinical Parallels, and Value for Drug Testing in Alzheimer's Disease of the APP[V717I] London Transgenic Mouse Model

The APP[V717I] London (APP-Ld) mouse model recapitulates important pathological and clinical hallmarks of Alzheimer's disease (AD) and is therefore a valuable paradigm for evaluating therapeutic candidates. Historically, both the parenchymal and vascular amyloid deposits, and more recently, tru...

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Detalles Bibliográficos
Autores principales: Tanghe, An, Termont, Annelies, Merchiers, Pascal, Schilling, Stephan, Demuth, Hans-Ulrich, Scrocchi, Louise, Van Leuven, Fred, Griffioen, Gerard, Van Dooren, Tom
Formato: Texto
Lenguaje:English
Publicado: SAGE-Hindawi Access to Research 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2939388/
https://www.ncbi.nlm.nih.gov/pubmed/20862386
http://dx.doi.org/10.4061/2010/417314

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2939388/
https://www.ncbi.nlm.nih.gov/pubmed/20862386
http://dx.doi.org/10.4061/2010/417314

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