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Identification of Myocardial Damage in Systemic Sclerosis: A Nuclear Cardiology Approach
Myocardial involvement is an important prognostic factor in patients with systemic sclerosis, and early diagnosis and staging of the disease have been sought after. Since myocardial damage is characterized by connective tissue disease, including fibrosis and diffuse vascular lesions or microcirculat...
Autores principales: | , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2939403/ https://www.ncbi.nlm.nih.gov/pubmed/20862337 http://dx.doi.org/10.1155/2010/496509 |
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author | Nakajima, Kenichi Matsuo, Shinro Hasegawa, Minoru Kinuya, Seigo Takehara, Kazuhiko |
author_facet | Nakajima, Kenichi Matsuo, Shinro Hasegawa, Minoru Kinuya, Seigo Takehara, Kazuhiko |
author_sort | Nakajima, Kenichi |
collection | PubMed |
description | Myocardial involvement is an important prognostic factor in patients with systemic sclerosis, and early diagnosis and staging of the disease have been sought after. Since myocardial damage is characterized by connective tissue disease, including fibrosis and diffuse vascular lesions or microcirculation, nuclear myocardial perfusion imaging has been a promising option for evaluating myocardial damages in early stages. In addition to the conventional stress-rest perfusion imaging, the current use of quantitative electrocardiographic gated imaging has contributed to more precise evaluation of cardiac perfusion, ventricular wall motion, and diastolic function, all of which have enhanced diagnostic ability of evaluating myocardial dysfunction. Abnormal sympathetic imaging with Iodine-123 metaiodobenzylguanidine might be another option for identifying myocardial damage. This paper deals with approaches from nuclear cardiology to detect perfusion and functional abnormality as an early sign of myocardial involvement as well as possible prognostic values in patients with abnormal imaging results. The role of nuclear cardiology in the era of multiple imaging modalities is discussed. |
format | Text |
id | pubmed-2939403 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-29394032010-09-22 Identification of Myocardial Damage in Systemic Sclerosis: A Nuclear Cardiology Approach Nakajima, Kenichi Matsuo, Shinro Hasegawa, Minoru Kinuya, Seigo Takehara, Kazuhiko Int J Rheumatol Review Article Myocardial involvement is an important prognostic factor in patients with systemic sclerosis, and early diagnosis and staging of the disease have been sought after. Since myocardial damage is characterized by connective tissue disease, including fibrosis and diffuse vascular lesions or microcirculation, nuclear myocardial perfusion imaging has been a promising option for evaluating myocardial damages in early stages. In addition to the conventional stress-rest perfusion imaging, the current use of quantitative electrocardiographic gated imaging has contributed to more precise evaluation of cardiac perfusion, ventricular wall motion, and diastolic function, all of which have enhanced diagnostic ability of evaluating myocardial dysfunction. Abnormal sympathetic imaging with Iodine-123 metaiodobenzylguanidine might be another option for identifying myocardial damage. This paper deals with approaches from nuclear cardiology to detect perfusion and functional abnormality as an early sign of myocardial involvement as well as possible prognostic values in patients with abnormal imaging results. The role of nuclear cardiology in the era of multiple imaging modalities is discussed. Hindawi Publishing Corporation 2010 2010-08-31 /pmc/articles/PMC2939403/ /pubmed/20862337 http://dx.doi.org/10.1155/2010/496509 Text en Copyright © 2010 Kenichi Nakajima et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Nakajima, Kenichi Matsuo, Shinro Hasegawa, Minoru Kinuya, Seigo Takehara, Kazuhiko Identification of Myocardial Damage in Systemic Sclerosis: A Nuclear Cardiology Approach |
title | Identification of Myocardial Damage in Systemic Sclerosis: A Nuclear Cardiology Approach |
title_full | Identification of Myocardial Damage in Systemic Sclerosis: A Nuclear Cardiology Approach |
title_fullStr | Identification of Myocardial Damage in Systemic Sclerosis: A Nuclear Cardiology Approach |
title_full_unstemmed | Identification of Myocardial Damage in Systemic Sclerosis: A Nuclear Cardiology Approach |
title_short | Identification of Myocardial Damage in Systemic Sclerosis: A Nuclear Cardiology Approach |
title_sort | identification of myocardial damage in systemic sclerosis: a nuclear cardiology approach |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2939403/ https://www.ncbi.nlm.nih.gov/pubmed/20862337 http://dx.doi.org/10.1155/2010/496509 |
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