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An Innovative Mathematical Model: A Key to the Riddle of HbA(1c)
HbA(1c) is a standard clinical assessment of glycemia and the basis of most data relating glycemic control to complications. While daily blood glucose testing gives a picture of day-to-day fluctuations, the HbA(1c) test offers an overview of how well glucose has been controlled over the past 4 month...
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Formato: | Texto |
Lenguaje: | English |
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Hindawi Publishing Corporation
2010
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2939406/ https://www.ncbi.nlm.nih.gov/pubmed/20871656 http://dx.doi.org/10.1155/2010/481326 |
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author | Kahrom, Mahdi |
author_facet | Kahrom, Mahdi |
author_sort | Kahrom, Mahdi |
collection | PubMed |
description | HbA(1c) is a standard clinical assessment of glycemia and the basis of most data relating glycemic control to complications. While daily blood glucose testing gives a picture of day-to-day fluctuations, the HbA(1c) test offers an overview of how well glucose has been controlled over the past 4 months. I devised an innovative mathematical model to describe novel equations governing HbA(1c) which enables analysis of HbA(1c) behavior and provides emerging new concepts in assessment of diabetes management. Linear relationship of HbA(1c) and mean plasma glucose along with the kinetic analysis of HbA(1c) formation has been used as the basic suppositions to construct this model. The main application of this devised model is prediction of mean plasma glucose at any desired point in time after a change in therapy and with great certainty. This model also appraises the pattern of HbA(1c) changes over time and provides a unique opportunity to address common mistakes and misconceptions in routine application of HbA(1c) that could have potentially important implications on diabetes control. |
format | Text |
id | pubmed-2939406 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-29394062010-09-24 An Innovative Mathematical Model: A Key to the Riddle of HbA(1c) Kahrom, Mahdi Int J Endocrinol Research Article HbA(1c) is a standard clinical assessment of glycemia and the basis of most data relating glycemic control to complications. While daily blood glucose testing gives a picture of day-to-day fluctuations, the HbA(1c) test offers an overview of how well glucose has been controlled over the past 4 months. I devised an innovative mathematical model to describe novel equations governing HbA(1c) which enables analysis of HbA(1c) behavior and provides emerging new concepts in assessment of diabetes management. Linear relationship of HbA(1c) and mean plasma glucose along with the kinetic analysis of HbA(1c) formation has been used as the basic suppositions to construct this model. The main application of this devised model is prediction of mean plasma glucose at any desired point in time after a change in therapy and with great certainty. This model also appraises the pattern of HbA(1c) changes over time and provides a unique opportunity to address common mistakes and misconceptions in routine application of HbA(1c) that could have potentially important implications on diabetes control. Hindawi Publishing Corporation 2010 2010-08-29 /pmc/articles/PMC2939406/ /pubmed/20871656 http://dx.doi.org/10.1155/2010/481326 Text en Copyright © 2010 Mahdi Kahrom. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Kahrom, Mahdi An Innovative Mathematical Model: A Key to the Riddle of HbA(1c) |
title | An Innovative Mathematical Model: A Key to the Riddle of HbA(1c)
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title_full | An Innovative Mathematical Model: A Key to the Riddle of HbA(1c)
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title_fullStr | An Innovative Mathematical Model: A Key to the Riddle of HbA(1c)
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title_full_unstemmed | An Innovative Mathematical Model: A Key to the Riddle of HbA(1c)
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title_short | An Innovative Mathematical Model: A Key to the Riddle of HbA(1c)
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title_sort | innovative mathematical model: a key to the riddle of hba(1c) |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2939406/ https://www.ncbi.nlm.nih.gov/pubmed/20871656 http://dx.doi.org/10.1155/2010/481326 |
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