Cargando…
Circadian Rhythm Disturbances in Patients with Alzheimer's Disease: A Review
Circadian Rhythm Disturbances (CRDs) affect as many as a quarter of Alzheimer's disease (AD) patients during some stage of their illness. Alterations in the suprachiasmatic nucleus and melatonin secretion are the major factors linked with the cause of CRDs. As a result, the normal physiology of...
Autores principales: | , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
SAGE-Hindawi Access to Research
2010
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2939436/ https://www.ncbi.nlm.nih.gov/pubmed/20862344 http://dx.doi.org/10.4061/2010/716453 |
_version_ | 1782186720365641728 |
---|---|
author | Weldemichael, Dawit A. Grossberg, George T. |
author_facet | Weldemichael, Dawit A. Grossberg, George T. |
author_sort | Weldemichael, Dawit A. |
collection | PubMed |
description | Circadian Rhythm Disturbances (CRDs) affect as many as a quarter of Alzheimer's disease (AD) patients during some stage of their illness. Alterations in the suprachiasmatic nucleus and melatonin secretion are the major factors linked with the cause of CRDs. As a result, the normal physiology of sleep, the biological clock, and core body temperature are affected. This paper systematically discusses some of the causative factors, typical symptoms, and treatment options for CRDs in patients with AD. This paper also emphasizes the implementation of behavioral and environmental therapies before embarking on medications to treat CRDs. Pharmacotherapeutic options are summarized to provide symptomatic benefits for the patient and relieve stress on their families and professional care providers. As of today, there are few studies relative to CRDs in AD. Large randomized trials are warranted to evaluate the effects of treatments such as bright light therapy and engaging activities in the reduction of CRDs in AD patients. |
format | Text |
id | pubmed-2939436 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | SAGE-Hindawi Access to Research |
record_format | MEDLINE/PubMed |
spelling | pubmed-29394362010-09-22 Circadian Rhythm Disturbances in Patients with Alzheimer's Disease: A Review Weldemichael, Dawit A. Grossberg, George T. Int J Alzheimers Dis Review Article Circadian Rhythm Disturbances (CRDs) affect as many as a quarter of Alzheimer's disease (AD) patients during some stage of their illness. Alterations in the suprachiasmatic nucleus and melatonin secretion are the major factors linked with the cause of CRDs. As a result, the normal physiology of sleep, the biological clock, and core body temperature are affected. This paper systematically discusses some of the causative factors, typical symptoms, and treatment options for CRDs in patients with AD. This paper also emphasizes the implementation of behavioral and environmental therapies before embarking on medications to treat CRDs. Pharmacotherapeutic options are summarized to provide symptomatic benefits for the patient and relieve stress on their families and professional care providers. As of today, there are few studies relative to CRDs in AD. Large randomized trials are warranted to evaluate the effects of treatments such as bright light therapy and engaging activities in the reduction of CRDs in AD patients. SAGE-Hindawi Access to Research 2010-09-02 /pmc/articles/PMC2939436/ /pubmed/20862344 http://dx.doi.org/10.4061/2010/716453 Text en Copyright © 2010 D. A. Weldemichael and G. T. Grossberg. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Weldemichael, Dawit A. Grossberg, George T. Circadian Rhythm Disturbances in Patients with Alzheimer's Disease: A Review |
title | Circadian Rhythm Disturbances in Patients with Alzheimer's Disease: A Review |
title_full | Circadian Rhythm Disturbances in Patients with Alzheimer's Disease: A Review |
title_fullStr | Circadian Rhythm Disturbances in Patients with Alzheimer's Disease: A Review |
title_full_unstemmed | Circadian Rhythm Disturbances in Patients with Alzheimer's Disease: A Review |
title_short | Circadian Rhythm Disturbances in Patients with Alzheimer's Disease: A Review |
title_sort | circadian rhythm disturbances in patients with alzheimer's disease: a review |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2939436/ https://www.ncbi.nlm.nih.gov/pubmed/20862344 http://dx.doi.org/10.4061/2010/716453 |
work_keys_str_mv | AT weldemichaeldawita circadianrhythmdisturbancesinpatientswithalzheimersdiseaseareview AT grossberggeorget circadianrhythmdisturbancesinpatientswithalzheimersdiseaseareview |