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COX-2 inhibition improves immunotherapy and is associated with decreased numbers of myeloid-derived suppressor cells in mesothelioma. Celecoxib influences MDSC function

BACKGROUND: Myeloid-derived suppressor cells (MDSC) are a heterogeneous population of immature cells that accumulates in tumour-bearing hosts. These cells are induced by tumour-derived factors (e.g. prostaglandins) and have a critical role in immune suppression. MDSC suppress T and NK cell function...

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Detalles Bibliográficos
Autores principales:	Veltman, Joris D, Lambers, Margaretha EH, van Nimwegen, Menno, Hendriks, Rudi W, Hoogsteden, Henk C, Aerts, Joachim GJV, Hegmans, Joost PJJ
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2939552/ https://www.ncbi.nlm.nih.gov/pubmed/20804550 http://dx.doi.org/10.1186/1471-2407-10-464

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