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Chk1 suppressed cell death
The role of Chk1 in the cellular response to DNA replication stress is well established. However recent work indicates a novel role for Chk1 in the suppression of apoptosis following the disruption of DNA replication or DNA damage. This review will consider these findings in the context of known pat...
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| Formato: | Texto |
| Lenguaje: | English |
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BioMed Central
2010
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2939633/ https://www.ncbi.nlm.nih.gov/pubmed/20813042 http://dx.doi.org/10.1186/1747-1028-5-21 |
| _version_ | 1782186754583822336 |
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| author | Meuth, Mark |
| author_facet | Meuth, Mark |
| author_sort | Meuth, Mark |
| collection | PubMed |
| description | The role of Chk1 in the cellular response to DNA replication stress is well established. However recent work indicates a novel role for Chk1 in the suppression of apoptosis following the disruption of DNA replication or DNA damage. This review will consider these findings in the context of known pathways of Chk1 signalling and potential applications of therapies that target Chk1. |
| format | Text |
| id | pubmed-2939633 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2010 |
| publisher | BioMed Central |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-29396332010-09-16 Chk1 suppressed cell death Meuth, Mark Cell Div Review The role of Chk1 in the cellular response to DNA replication stress is well established. However recent work indicates a novel role for Chk1 in the suppression of apoptosis following the disruption of DNA replication or DNA damage. This review will consider these findings in the context of known pathways of Chk1 signalling and potential applications of therapies that target Chk1. BioMed Central 2010-09-02 /pmc/articles/PMC2939633/ /pubmed/20813042 http://dx.doi.org/10.1186/1747-1028-5-21 Text en Copyright ©2010 Meuth; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| spellingShingle | Review Meuth, Mark Chk1 suppressed cell death |
| title | Chk1 suppressed cell death |
| title_full | Chk1 suppressed cell death |
| title_fullStr | Chk1 suppressed cell death |
| title_full_unstemmed | Chk1 suppressed cell death |
| title_short | Chk1 suppressed cell death |
| title_sort | chk1 suppressed cell death |
| topic | Review |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2939633/ https://www.ncbi.nlm.nih.gov/pubmed/20813042 http://dx.doi.org/10.1186/1747-1028-5-21 |
| work_keys_str_mv | AT meuthmark chk1suppressedcelldeath |