Tiotropium bromide inhibits TGF-β-induced MMP production from lung fibroblasts by interfering with Smad and MAPK pathways in vitro

BACKGROUND: Chronic obstructive pulmonary disease (COPD) is characterized by chronic inflammation and structural alterations (ie, tissue remodeling) throughout the conducting airways, parenchyma, and pulmonary vasculature. Matrix metalloproteinases (MMPs) are extracellular degrading enzymes that pla...

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Detalles Bibliográficos
Autores principales: Asano, Kazuhito, Shikama, Yusuke, Shoji, Naruo, Hirano, Kojiro, Suzaki, Harumi, Nakajima, Hiroaki
Formato: Texto
Lenguaje:English
Publicado: Dove Medical Press 2010
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2939683/
https://www.ncbi.nlm.nih.gov/pubmed/20856827

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