Cellular senescence predicts treatment outcome in metastasised colorectal cancer

BACKGROUND: Cellular senescence is a terminal cell-cycle arrest that occurs in response to activated oncogenes and DNA-damaging chemotherapy. Whether cancer cell senescence at diagnosis might be predictive for treatment outcome is unknown. METHODS: A senescence index (SI) was developed and used to r...

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Autores principales: Haugstetter, A M, Loddenkemper, C, Lenze, D, Gröne, J, Standfuß, C, Petersen, I, Dörken, B, Schmitt, C A
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2010
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2939783/
https://www.ncbi.nlm.nih.gov/pubmed/20628375
http://dx.doi.org/10.1038/sj.bjc.6605784
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author Haugstetter, A M
Loddenkemper, C
Lenze, D
Gröne, J
Standfuß, C
Petersen, I
Dörken, B
Schmitt, C A
author_facet Haugstetter, A M
Loddenkemper, C
Lenze, D
Gröne, J
Standfuß, C
Petersen, I
Dörken, B
Schmitt, C A
author_sort Haugstetter, A M
collection PubMed
description BACKGROUND: Cellular senescence is a terminal cell-cycle arrest that occurs in response to activated oncogenes and DNA-damaging chemotherapy. Whether cancer cell senescence at diagnosis might be predictive for treatment outcome is unknown. METHODS: A senescence index (SI) was developed and used to retrospectively correlate the treatment outcome of 30 UICC stage IV colorectal cancer (CRC) patients with their SI at diagnosis. RESULTS: 5-Fluorouracil/leucovorin-treated CRC patients achieved a significantly longer progression-free survival when presenting with SI-positive tumours before therapy (median 12.0 vs 6.0 months; P=0.044). CONCLUSION: Cancer cell senescence predicts treatment outcome in metastasised CRC. Prospective analyses of larger patient cohorts are needed.
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spelling pubmed-29397832011-08-10 Cellular senescence predicts treatment outcome in metastasised colorectal cancer Haugstetter, A M Loddenkemper, C Lenze, D Gröne, J Standfuß, C Petersen, I Dörken, B Schmitt, C A Br J Cancer Short Communication BACKGROUND: Cellular senescence is a terminal cell-cycle arrest that occurs in response to activated oncogenes and DNA-damaging chemotherapy. Whether cancer cell senescence at diagnosis might be predictive for treatment outcome is unknown. METHODS: A senescence index (SI) was developed and used to retrospectively correlate the treatment outcome of 30 UICC stage IV colorectal cancer (CRC) patients with their SI at diagnosis. RESULTS: 5-Fluorouracil/leucovorin-treated CRC patients achieved a significantly longer progression-free survival when presenting with SI-positive tumours before therapy (median 12.0 vs 6.0 months; P=0.044). CONCLUSION: Cancer cell senescence predicts treatment outcome in metastasised CRC. Prospective analyses of larger patient cohorts are needed. Nature Publishing Group 2010-08-10 2010-07-13 /pmc/articles/PMC2939783/ /pubmed/20628375 http://dx.doi.org/10.1038/sj.bjc.6605784 Text en Copyright © 2010 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Short Communication
Haugstetter, A M
Loddenkemper, C
Lenze, D
Gröne, J
Standfuß, C
Petersen, I
Dörken, B
Schmitt, C A
Cellular senescence predicts treatment outcome in metastasised colorectal cancer
title Cellular senescence predicts treatment outcome in metastasised colorectal cancer
title_full Cellular senescence predicts treatment outcome in metastasised colorectal cancer
title_fullStr Cellular senescence predicts treatment outcome in metastasised colorectal cancer
title_full_unstemmed Cellular senescence predicts treatment outcome in metastasised colorectal cancer
title_short Cellular senescence predicts treatment outcome in metastasised colorectal cancer
title_sort cellular senescence predicts treatment outcome in metastasised colorectal cancer
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2939783/
https://www.ncbi.nlm.nih.gov/pubmed/20628375
http://dx.doi.org/10.1038/sj.bjc.6605784
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