Effect of ABCB1 C3435T polymorphism on docetaxel pharmacokinetics according to menopausal status in breast cancer patients

BACKGROUND: It can be hypothesised that inherited polymorphisms in the drug-transporter ABCB1 gene may interfere with interindividual variations in drug response in breast cancer patients. Docetaxel is a substrate for ABCB1 whose function has been shown to be modulated by oestrogen and progesterone....

Descripción completa

Detalles Bibliográficos
Autores principales: Fajac, A, Gligorov, J, Rezai, K, Lévy, P, Lévy, E, Selle, F, Beerblock, K, Avenin, D, Saintigny, P, Hugonin, S, Bernaudin, J-F, Lokiec, F
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2010
Materias:
Molecular Diagnostics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2939787/
https://www.ncbi.nlm.nih.gov/pubmed/20628376
http://dx.doi.org/10.1038/sj.bjc.6605789

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2939787/
https://www.ncbi.nlm.nih.gov/pubmed/20628376
http://dx.doi.org/10.1038/sj.bjc.6605789

Ejemplares similares