Neutralisation of uPA with a Monoclonal Antibody Reduces Plasmin Formation and Delays Skin Wound Healing in tPA-Deficient Mice

BACKGROUND: Proteolytic degradation by plasmin and metalloproteinases is essential for epidermal regeneration in skin wound healing. Plasminogen deficient mice have severely delayed wound closure as have mice simultaneously lacking the two plasminogen activators, urokinase-type plasminogen activator...

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Detalles Bibliográficos
Autores principales: Jögi, Annika, Rønø, Birgitte, Lund, Ida K., Nielsen, Boye S., Ploug, Michael, Høyer-Hansen, Gunilla, Rømer, John, Lund, Leif R.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2939870/
https://www.ncbi.nlm.nih.gov/pubmed/20856796
http://dx.doi.org/10.1371/journal.pone.0012746

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