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Doxorubicin In Vivo Rapidly Alters Expression and Translation of Myocardial Electron Transport Chain Genes, Leads to ATP Loss and Caspase 3 Activation

BACKGROUND: Doxorubicin is one of the most effective anti-cancer drugs but its use is limited by cumulative cardiotoxicity that restricts lifetime dose. Redox damage is one of the most accepted mechanisms of toxicity, but not fully substantiated. Moreover doxorubicin is not an efficient redox cyclin...

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Detalles Bibliográficos
Autores principales:	Pointon, Amy V., Walker, Tracy M., Phillips, Kate M., Luo, Jinli, Riley, Joan, Zhang, Shu-Dong, Parry, Joel D., Lyon, Jonathan J., Marczylo, Emma L., Gant, Timothy W.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2939875/ https://www.ncbi.nlm.nih.gov/pubmed/20856801 http://dx.doi.org/10.1371/journal.pone.0012733

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