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Akt Deficiency Attenuates Muscle Size and Function but Not the Response to ActRIIB Inhibition
BACKGROUND: Akt is a critical mediator of developmental skeletal muscle growth. Treatment with a soluble ActRIIB fusion protein (ActRIIB-mFc) increases skeletal muscle mass and strength by inhibiting myostatin and related peptides. Recent in vitro studies have suggested that Akt signaling is necessa...
| Autores principales: | , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2939888/ https://www.ncbi.nlm.nih.gov/pubmed/20856813 http://dx.doi.org/10.1371/journal.pone.0012707 |