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Schistosomiasis Coinfection in Children Influences Acquired Immune Response against Plasmodium falciparum Malaria Antigens
BACKGROUND: Malaria and schistosomiasis coinfection frequently occurs in tropical countries. This study evaluates the influence of Schistosoma haematobium infection on specific antibody responses and cytokine production to recombinant merozoite surface protein-1-19 (MSP1-(19)) and schizont extract o...
Autores principales: | , , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Public Library of Science
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2939900/ https://www.ncbi.nlm.nih.gov/pubmed/20856680 http://dx.doi.org/10.1371/journal.pone.0012764 |
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author | Diallo, Tamsir O. Remoue, Franck Gaayeb, Lobna Schacht, Anne-Marie Charrier, Nicole De Clerck, Dick Dompnier, Jean-Pierre Pillet, Sophie Garraud, Olivier N'Diaye, Abdoulaye A. Riveau, Gilles |
author_facet | Diallo, Tamsir O. Remoue, Franck Gaayeb, Lobna Schacht, Anne-Marie Charrier, Nicole De Clerck, Dick Dompnier, Jean-Pierre Pillet, Sophie Garraud, Olivier N'Diaye, Abdoulaye A. Riveau, Gilles |
author_sort | Diallo, Tamsir O. |
collection | PubMed |
description | BACKGROUND: Malaria and schistosomiasis coinfection frequently occurs in tropical countries. This study evaluates the influence of Schistosoma haematobium infection on specific antibody responses and cytokine production to recombinant merozoite surface protein-1-19 (MSP1-(19)) and schizont extract of Plasmodium falciparum in malaria-infected children. METHODOLOGY: Specific IgG1 to MSP1-(19), as well as IgG1 and IgG3 to schizont extract were significantly increased in coinfected children compared to P. falciparum mono-infected children. Stimulation with MSP1-(19) lead to a specific production of both interleukin-10 (IL-10) and interferon-γ (IFN-γ), whereas the stimulation with schizont extract produced an IL-10 response only in the coinfected group. CONCLUSIONS: Our study suggests that schistosomiasis coinfection favours anti-malarial protective antibody responses, which could be associated with the regulation of IL-10 and IFN-γ production and seems to be antigen-dependent. This study demonstrates the importance of infectious status of the population in the evaluation of acquired immunity against malaria and highlights the consequences of a multiple infection environment during clinical trials of anti-malaria vaccine candidates. |
format | Text |
id | pubmed-2939900 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-29399002010-09-20 Schistosomiasis Coinfection in Children Influences Acquired Immune Response against Plasmodium falciparum Malaria Antigens Diallo, Tamsir O. Remoue, Franck Gaayeb, Lobna Schacht, Anne-Marie Charrier, Nicole De Clerck, Dick Dompnier, Jean-Pierre Pillet, Sophie Garraud, Olivier N'Diaye, Abdoulaye A. Riveau, Gilles PLoS One Research Article BACKGROUND: Malaria and schistosomiasis coinfection frequently occurs in tropical countries. This study evaluates the influence of Schistosoma haematobium infection on specific antibody responses and cytokine production to recombinant merozoite surface protein-1-19 (MSP1-(19)) and schizont extract of Plasmodium falciparum in malaria-infected children. METHODOLOGY: Specific IgG1 to MSP1-(19), as well as IgG1 and IgG3 to schizont extract were significantly increased in coinfected children compared to P. falciparum mono-infected children. Stimulation with MSP1-(19) lead to a specific production of both interleukin-10 (IL-10) and interferon-γ (IFN-γ), whereas the stimulation with schizont extract produced an IL-10 response only in the coinfected group. CONCLUSIONS: Our study suggests that schistosomiasis coinfection favours anti-malarial protective antibody responses, which could be associated with the regulation of IL-10 and IFN-γ production and seems to be antigen-dependent. This study demonstrates the importance of infectious status of the population in the evaluation of acquired immunity against malaria and highlights the consequences of a multiple infection environment during clinical trials of anti-malaria vaccine candidates. Public Library of Science 2010-09-15 /pmc/articles/PMC2939900/ /pubmed/20856680 http://dx.doi.org/10.1371/journal.pone.0012764 Text en Diallo et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Diallo, Tamsir O. Remoue, Franck Gaayeb, Lobna Schacht, Anne-Marie Charrier, Nicole De Clerck, Dick Dompnier, Jean-Pierre Pillet, Sophie Garraud, Olivier N'Diaye, Abdoulaye A. Riveau, Gilles Schistosomiasis Coinfection in Children Influences Acquired Immune Response against Plasmodium falciparum Malaria Antigens |
title | Schistosomiasis Coinfection in Children Influences Acquired Immune Response against Plasmodium falciparum Malaria Antigens |
title_full | Schistosomiasis Coinfection in Children Influences Acquired Immune Response against Plasmodium falciparum Malaria Antigens |
title_fullStr | Schistosomiasis Coinfection in Children Influences Acquired Immune Response against Plasmodium falciparum Malaria Antigens |
title_full_unstemmed | Schistosomiasis Coinfection in Children Influences Acquired Immune Response against Plasmodium falciparum Malaria Antigens |
title_short | Schistosomiasis Coinfection in Children Influences Acquired Immune Response against Plasmodium falciparum Malaria Antigens |
title_sort | schistosomiasis coinfection in children influences acquired immune response against plasmodium falciparum malaria antigens |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2939900/ https://www.ncbi.nlm.nih.gov/pubmed/20856680 http://dx.doi.org/10.1371/journal.pone.0012764 |
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