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Schistosomiasis Coinfection in Children Influences Acquired Immune Response against Plasmodium falciparum Malaria Antigens

BACKGROUND: Malaria and schistosomiasis coinfection frequently occurs in tropical countries. This study evaluates the influence of Schistosoma haematobium infection on specific antibody responses and cytokine production to recombinant merozoite surface protein-1-19 (MSP1-(19)) and schizont extract o...

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Autores principales: Diallo, Tamsir O., Remoue, Franck, Gaayeb, Lobna, Schacht, Anne-Marie, Charrier, Nicole, De Clerck, Dick, Dompnier, Jean-Pierre, Pillet, Sophie, Garraud, Olivier, N'Diaye, Abdoulaye A., Riveau, Gilles
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2939900/
https://www.ncbi.nlm.nih.gov/pubmed/20856680
http://dx.doi.org/10.1371/journal.pone.0012764
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author Diallo, Tamsir O.
Remoue, Franck
Gaayeb, Lobna
Schacht, Anne-Marie
Charrier, Nicole
De Clerck, Dick
Dompnier, Jean-Pierre
Pillet, Sophie
Garraud, Olivier
N'Diaye, Abdoulaye A.
Riveau, Gilles
author_facet Diallo, Tamsir O.
Remoue, Franck
Gaayeb, Lobna
Schacht, Anne-Marie
Charrier, Nicole
De Clerck, Dick
Dompnier, Jean-Pierre
Pillet, Sophie
Garraud, Olivier
N'Diaye, Abdoulaye A.
Riveau, Gilles
author_sort Diallo, Tamsir O.
collection PubMed
description BACKGROUND: Malaria and schistosomiasis coinfection frequently occurs in tropical countries. This study evaluates the influence of Schistosoma haematobium infection on specific antibody responses and cytokine production to recombinant merozoite surface protein-1-19 (MSP1-(19)) and schizont extract of Plasmodium falciparum in malaria-infected children. METHODOLOGY: Specific IgG1 to MSP1-(19), as well as IgG1 and IgG3 to schizont extract were significantly increased in coinfected children compared to P. falciparum mono-infected children. Stimulation with MSP1-(19) lead to a specific production of both interleukin-10 (IL-10) and interferon-γ (IFN-γ), whereas the stimulation with schizont extract produced an IL-10 response only in the coinfected group. CONCLUSIONS: Our study suggests that schistosomiasis coinfection favours anti-malarial protective antibody responses, which could be associated with the regulation of IL-10 and IFN-γ production and seems to be antigen-dependent. This study demonstrates the importance of infectious status of the population in the evaluation of acquired immunity against malaria and highlights the consequences of a multiple infection environment during clinical trials of anti-malaria vaccine candidates.
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spelling pubmed-29399002010-09-20 Schistosomiasis Coinfection in Children Influences Acquired Immune Response against Plasmodium falciparum Malaria Antigens Diallo, Tamsir O. Remoue, Franck Gaayeb, Lobna Schacht, Anne-Marie Charrier, Nicole De Clerck, Dick Dompnier, Jean-Pierre Pillet, Sophie Garraud, Olivier N'Diaye, Abdoulaye A. Riveau, Gilles PLoS One Research Article BACKGROUND: Malaria and schistosomiasis coinfection frequently occurs in tropical countries. This study evaluates the influence of Schistosoma haematobium infection on specific antibody responses and cytokine production to recombinant merozoite surface protein-1-19 (MSP1-(19)) and schizont extract of Plasmodium falciparum in malaria-infected children. METHODOLOGY: Specific IgG1 to MSP1-(19), as well as IgG1 and IgG3 to schizont extract were significantly increased in coinfected children compared to P. falciparum mono-infected children. Stimulation with MSP1-(19) lead to a specific production of both interleukin-10 (IL-10) and interferon-γ (IFN-γ), whereas the stimulation with schizont extract produced an IL-10 response only in the coinfected group. CONCLUSIONS: Our study suggests that schistosomiasis coinfection favours anti-malarial protective antibody responses, which could be associated with the regulation of IL-10 and IFN-γ production and seems to be antigen-dependent. This study demonstrates the importance of infectious status of the population in the evaluation of acquired immunity against malaria and highlights the consequences of a multiple infection environment during clinical trials of anti-malaria vaccine candidates. Public Library of Science 2010-09-15 /pmc/articles/PMC2939900/ /pubmed/20856680 http://dx.doi.org/10.1371/journal.pone.0012764 Text en Diallo et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Diallo, Tamsir O.
Remoue, Franck
Gaayeb, Lobna
Schacht, Anne-Marie
Charrier, Nicole
De Clerck, Dick
Dompnier, Jean-Pierre
Pillet, Sophie
Garraud, Olivier
N'Diaye, Abdoulaye A.
Riveau, Gilles
Schistosomiasis Coinfection in Children Influences Acquired Immune Response against Plasmodium falciparum Malaria Antigens
title Schistosomiasis Coinfection in Children Influences Acquired Immune Response against Plasmodium falciparum Malaria Antigens
title_full Schistosomiasis Coinfection in Children Influences Acquired Immune Response against Plasmodium falciparum Malaria Antigens
title_fullStr Schistosomiasis Coinfection in Children Influences Acquired Immune Response against Plasmodium falciparum Malaria Antigens
title_full_unstemmed Schistosomiasis Coinfection in Children Influences Acquired Immune Response against Plasmodium falciparum Malaria Antigens
title_short Schistosomiasis Coinfection in Children Influences Acquired Immune Response against Plasmodium falciparum Malaria Antigens
title_sort schistosomiasis coinfection in children influences acquired immune response against plasmodium falciparum malaria antigens
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2939900/
https://www.ncbi.nlm.nih.gov/pubmed/20856680
http://dx.doi.org/10.1371/journal.pone.0012764
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