Polymorphisms in the multiple drug resistance protein 1 and in P-glycoprotein 1 are associated with time to event outcomes in patients with advanced multiple myeloma treated with bortezomib and pegylated liposomal doxorubicin

Single nucleotide polymorphisms (SNPs) in the multiple drug resistance protein 1 (MRP1) and P-glycoprotein 1 (MDR1) genes modulate their ability to mediate drug resistance. We therefore sought to retrospectively evaluate their influence on outcomes in relapsed and/or refractory myeloma patients trea...

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Detalles Bibliográficos
Autores principales: Buda, Gabriele, Ricci, Deborah, Huang, C. Chris, Favis, Reyna, Cohen, Nadine, Zhuang, Sen H., Harousseau, Jean-Luc, Sonneveld, Pieter, Bladé, Joan, Orlowski, Robert Z.
Formato: Texto
Lenguaje:English
Publicado: Springer-Verlag 2010
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2940014/
https://www.ncbi.nlm.nih.gov/pubmed/20532504
http://dx.doi.org/10.1007/s00277-010-0992-3

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