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mTOR signaling in glioblastoma: lessons learned from bench to bedside

Phosphatidyl-inositol-3 kinases (PI3Ks) constitute a family of intracellular lipid kinases that are frequently hyperactivated in glioblastoma. The PI3K complex links growth factor signaling with cellular proliferation, differentiation, metabolism, and survival. Mammalian target of rapamycin (mTOR) a...

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Detalles Bibliográficos
Autores principales:	Akhavan, David, Cloughesy, Timothy F., Mischel, Paul S.
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2010
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2940679/ https://www.ncbi.nlm.nih.gov/pubmed/20472883 http://dx.doi.org/10.1093/neuonc/noq052

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