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Molecular mechanisms and treatment strategies for Dupuytren’s disease

Dupuytren’s disease (DD) is a common disease of the hand and is characterized by thickening of the palmar fascia and formation of tight collagenous disease cords. At present, the disease is incurable and the molecular pathophysiology of DD is unknown. Surgery remains the most commonly used treatment...

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Detalles Bibliográficos
Autores principales: O’Gorman, David B, Vi, Linda, Gan, Bing Siang
Formato: Texto
Lenguaje:English
Publicado: Dove Medical Press 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2940746/
https://www.ncbi.nlm.nih.gov/pubmed/20856684
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author O’Gorman, David B
Vi, Linda
Gan, Bing Siang
author_facet O’Gorman, David B
Vi, Linda
Gan, Bing Siang
author_sort O’Gorman, David B
collection PubMed
description Dupuytren’s disease (DD) is a common disease of the hand and is characterized by thickening of the palmar fascia and formation of tight collagenous disease cords. At present, the disease is incurable and the molecular pathophysiology of DD is unknown. Surgery remains the most commonly used treatment for DD, but this requires extensive postoperative therapy and is associated with high rates of recurrence. Over the past decades, more indepth exploration of the molecular basis of DD has raised the hopes of developing new treatment modalities. This paper reviews the clinical presentation and molecular pathophysiology of this disease, as well as current and emerging treatment. It also explores the implications of new findings in the laboratory for future treatment.
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spelling pubmed-29407462010-09-20 Molecular mechanisms and treatment strategies for Dupuytren’s disease O’Gorman, David B Vi, Linda Gan, Bing Siang Ther Clin Risk Manag Review Dupuytren’s disease (DD) is a common disease of the hand and is characterized by thickening of the palmar fascia and formation of tight collagenous disease cords. At present, the disease is incurable and the molecular pathophysiology of DD is unknown. Surgery remains the most commonly used treatment for DD, but this requires extensive postoperative therapy and is associated with high rates of recurrence. Over the past decades, more indepth exploration of the molecular basis of DD has raised the hopes of developing new treatment modalities. This paper reviews the clinical presentation and molecular pathophysiology of this disease, as well as current and emerging treatment. It also explores the implications of new findings in the laboratory for future treatment. Dove Medical Press 2010 2010-09-07 /pmc/articles/PMC2940746/ /pubmed/20856684 Text en © 2010 O’Gorman et al, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.
spellingShingle Review
O’Gorman, David B
Vi, Linda
Gan, Bing Siang
Molecular mechanisms and treatment strategies for Dupuytren’s disease
title Molecular mechanisms and treatment strategies for Dupuytren’s disease
title_full Molecular mechanisms and treatment strategies for Dupuytren’s disease
title_fullStr Molecular mechanisms and treatment strategies for Dupuytren’s disease
title_full_unstemmed Molecular mechanisms and treatment strategies for Dupuytren’s disease
title_short Molecular mechanisms and treatment strategies for Dupuytren’s disease
title_sort molecular mechanisms and treatment strategies for dupuytren’s disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2940746/
https://www.ncbi.nlm.nih.gov/pubmed/20856684
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