The N-Terminal Domain of the Arenavirus L Protein Is an RNA Endonuclease Essential in mRNA Transcription

Arenaviridae synthesize viral mRNAs using short capped primers presumably acquired from cellular transcripts by a ‘cap-snatching’ mechanism. Here, we report the crystal structure and functional characterization of the N-terminal 196 residues (NL1) of the L protein from the prototypic arenavirus: lym...

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Detalles Bibliográficos
Autores principales: Morin, Benjamin, Coutard, Bruno, Lelke, Michaela, Ferron, François, Kerber, Romy, Jamal, Saïd, Frangeul, Antoine, Baronti, Cécile, Charrel, Rémi, de Lamballerie, Xavier, Vonrhein, Clemens, Lescar, Julien, Bricogne, Gérard, Günther, Stephan, Canard, Bruno
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2940758/
https://www.ncbi.nlm.nih.gov/pubmed/20862324
http://dx.doi.org/10.1371/journal.ppat.1001038

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