Allelic Variation at the 8q23.3 Colorectal Cancer Risk Locus Functions as a Cis-Acting Regulator of EIF3H

Common genetic variation at human 8q23.3 is significantly associated with colorectal cancer (CRC) risk. To elucidate the basis of this association we compared the frequency of common variants at 8q23.3 in 1,964 CRC cases and 2,081 healthy controls. Reporter gene studies showed that the single nucleo...

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Detalles Bibliográficos
Autores principales: Pittman, Alan M., Naranjo, Silvia, Jalava, Sanni E., Twiss, Philip, Ma, Yussanne, Olver, Bianca, Lloyd, Amy, Vijayakrishnan, Jayaram, Qureshi, Mobshra, Broderick, Peter, van Wezel, Tom, Morreau, Hans, Tuupanen, Sari, Aaltonen, Lauri A., Alonso, M. Eva, Manzanares, Miguel, Gavilán, Angela, Visakorpi, Tapio, Gómez-Skarmeta, José Luis, Houlston, Richard S.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2940760/
https://www.ncbi.nlm.nih.gov/pubmed/20862326
http://dx.doi.org/10.1371/journal.pgen.1001126

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