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ErbB2 enhances mammary tumorigenesis, oncogene-independent recurrence and metastasis in a model of IGF-IR-mediated mammary tumorigenesis

BACKGROUND: The type I insulin-like growth factor receptor (IGF-IR) and ErbB2 (Her-2) are receptor tyrosine kinases implicated in human breast cancer. Both proteins are currently the subject of targeted therapeutics that are used in the treatment of breast cancer or which are in clinical trials. The...

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Detalles Bibliográficos
Autores principales:	Campbell, Craig I, Petrik, James J, Moorehead, Roger A
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2010
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2940847/ https://www.ncbi.nlm.nih.gov/pubmed/20825649 http://dx.doi.org/10.1186/1476-4598-9-235

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