Loss of c-Met Disrupts Gene Expression Program Required for G2/M Progression during Liver Regeneration in Mice

BACKGROUND: Previous work has established that HGF/c-Met signaling plays a pivotal role in regulating the onset of S phase following partial hepatectomy (PH). In this study, we used Met(fl/fl);Alb-Cre(+/−) conditional knockout mice to determine the effects of c-Met dysfunction in hepatocytes on kine...

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Detalles Bibliográficos
Autores principales: Factor, Valentina M., Seo, Daekwan, Ishikawa, Tsuyoshi, Kaposi-Novak, Pal, Marquardt, Jens U., Andersen, Jesper B., Conner, Elizabeth A., Thorgeirsson, Snorri S.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2940888/
https://www.ncbi.nlm.nih.gov/pubmed/20862286
http://dx.doi.org/10.1371/journal.pone.0012739

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