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Controlling the direction of division
Quyn and colleagues report that gut stem cells have a biased spindle orientation and asymmetric retention of label-retaining DNA. These features are lost in mouse and human tissues when the microtubule binding protein Apc is mutated. In the developing kidney, Apc acts downstream from primary cilium...
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2010
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2941113/ https://www.ncbi.nlm.nih.gov/pubmed/20670393 http://dx.doi.org/10.1186/scrt21 |
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author | Satir, Peter |
author_facet | Satir, Peter |
author_sort | Satir, Peter |
collection | PubMed |
description | Quyn and colleagues report that gut stem cells have a biased spindle orientation and asymmetric retention of label-retaining DNA. These features are lost in mouse and human tissues when the microtubule binding protein Apc is mutated. In the developing kidney, Apc acts downstream from primary cilium signaling to influence spindle orientation when noncanonical Wnt signaling predominates. Do gut stem cells also have primary cilia? |
format | Text |
id | pubmed-2941113 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-29411132011-07-23 Controlling the direction of division Satir, Peter Stem Cell Res Ther Commentary Quyn and colleagues report that gut stem cells have a biased spindle orientation and asymmetric retention of label-retaining DNA. These features are lost in mouse and human tissues when the microtubule binding protein Apc is mutated. In the developing kidney, Apc acts downstream from primary cilium signaling to influence spindle orientation when noncanonical Wnt signaling predominates. Do gut stem cells also have primary cilia? BioMed Central 2010-07-23 /pmc/articles/PMC2941113/ /pubmed/20670393 http://dx.doi.org/10.1186/scrt21 Text en Copyright ©2010 BioMed Central Ltd |
spellingShingle | Commentary Satir, Peter Controlling the direction of division |
title | Controlling the direction of division |
title_full | Controlling the direction of division |
title_fullStr | Controlling the direction of division |
title_full_unstemmed | Controlling the direction of division |
title_short | Controlling the direction of division |
title_sort | controlling the direction of division |
topic | Commentary |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2941113/ https://www.ncbi.nlm.nih.gov/pubmed/20670393 http://dx.doi.org/10.1186/scrt21 |
work_keys_str_mv | AT satirpeter controllingthedirectionofdivision |