Controlling the direction of division

Quyn and colleagues report that gut stem cells have a biased spindle orientation and asymmetric retention of label-retaining DNA. These features are lost in mouse and human tissues when the microtubule binding protein Apc is mutated. In the developing kidney, Apc acts downstream from primary cilium...

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Detalles Bibliográficos
Autor principal: Satir, Peter
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2941113/
https://www.ncbi.nlm.nih.gov/pubmed/20670393
http://dx.doi.org/10.1186/scrt21
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author Satir, Peter
author_facet Satir, Peter
author_sort Satir, Peter
collection PubMed
description Quyn and colleagues report that gut stem cells have a biased spindle orientation and asymmetric retention of label-retaining DNA. These features are lost in mouse and human tissues when the microtubule binding protein Apc is mutated. In the developing kidney, Apc acts downstream from primary cilium signaling to influence spindle orientation when noncanonical Wnt signaling predominates. Do gut stem cells also have primary cilia?
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spelling pubmed-29411132011-07-23 Controlling the direction of division Satir, Peter Stem Cell Res Ther Commentary Quyn and colleagues report that gut stem cells have a biased spindle orientation and asymmetric retention of label-retaining DNA. These features are lost in mouse and human tissues when the microtubule binding protein Apc is mutated. In the developing kidney, Apc acts downstream from primary cilium signaling to influence spindle orientation when noncanonical Wnt signaling predominates. Do gut stem cells also have primary cilia? BioMed Central 2010-07-23 /pmc/articles/PMC2941113/ /pubmed/20670393 http://dx.doi.org/10.1186/scrt21 Text en Copyright ©2010 BioMed Central Ltd
spellingShingle Commentary
Satir, Peter
Controlling the direction of division
title Controlling the direction of division
title_full Controlling the direction of division
title_fullStr Controlling the direction of division
title_full_unstemmed Controlling the direction of division
title_short Controlling the direction of division
title_sort controlling the direction of division
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2941113/
https://www.ncbi.nlm.nih.gov/pubmed/20670393
http://dx.doi.org/10.1186/scrt21
work_keys_str_mv AT satirpeter controllingthedirectionofdivision

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