Advances in mesenchymal stem cell-mediated gene therapy for cancer

Mesenchymal stem cells have a natural tropism for tumours and their metastases, and are also considered immunoprivileged. This remarkable combination of properties has formed the basis for many studies investigating their potential as tumour-specific delivery vehicles for suicide genes, oncolytic vi...

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Detalles Bibliográficos
Autores principales: Dwyer, Roisin M, Khan, Sonja, Barry, Frank P, O'Brien, Timothy, Kerin, Michael J
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2941117/
https://www.ncbi.nlm.nih.gov/pubmed/20699014
http://dx.doi.org/10.1186/scrt25
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author Dwyer, Roisin M
Khan, Sonja
Barry, Frank P
O'Brien, Timothy
Kerin, Michael J
author_facet Dwyer, Roisin M
Khan, Sonja
Barry, Frank P
O'Brien, Timothy
Kerin, Michael J
author_sort Dwyer, Roisin M
collection PubMed
description Mesenchymal stem cells have a natural tropism for tumours and their metastases, and are also considered immunoprivileged. This remarkable combination of properties has formed the basis for many studies investigating their potential as tumour-specific delivery vehicles for suicide genes, oncolytic viruses and secreted therapeutic proteins. The aim of the present review is to discuss the range of approaches that have been used to exploit the tumour-homing capacity of mesenchymal stem cells for gene delivery, and to highlight advances required to realize the full potential of this promising approach.
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spelling pubmed-29411172011-08-09 Advances in mesenchymal stem cell-mediated gene therapy for cancer Dwyer, Roisin M Khan, Sonja Barry, Frank P O'Brien, Timothy Kerin, Michael J Stem Cell Res Ther Review Mesenchymal stem cells have a natural tropism for tumours and their metastases, and are also considered immunoprivileged. This remarkable combination of properties has formed the basis for many studies investigating their potential as tumour-specific delivery vehicles for suicide genes, oncolytic viruses and secreted therapeutic proteins. The aim of the present review is to discuss the range of approaches that have been used to exploit the tumour-homing capacity of mesenchymal stem cells for gene delivery, and to highlight advances required to realize the full potential of this promising approach. BioMed Central 2010-08-09 /pmc/articles/PMC2941117/ /pubmed/20699014 http://dx.doi.org/10.1186/scrt25 Text en Copyright ©2010 BioMed Central Ltd
spellingShingle Review
Dwyer, Roisin M
Khan, Sonja
Barry, Frank P
O'Brien, Timothy
Kerin, Michael J
Advances in mesenchymal stem cell-mediated gene therapy for cancer
title Advances in mesenchymal stem cell-mediated gene therapy for cancer
title_full Advances in mesenchymal stem cell-mediated gene therapy for cancer
title_fullStr Advances in mesenchymal stem cell-mediated gene therapy for cancer
title_full_unstemmed Advances in mesenchymal stem cell-mediated gene therapy for cancer
title_short Advances in mesenchymal stem cell-mediated gene therapy for cancer
title_sort advances in mesenchymal stem cell-mediated gene therapy for cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2941117/
https://www.ncbi.nlm.nih.gov/pubmed/20699014
http://dx.doi.org/10.1186/scrt25
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AT khansonja advancesinmesenchymalstemcellmediatedgenetherapyforcancer
AT barryfrankp advancesinmesenchymalstemcellmediatedgenetherapyforcancer
AT obrientimothy advancesinmesenchymalstemcellmediatedgenetherapyforcancer
AT kerinmichaelj advancesinmesenchymalstemcellmediatedgenetherapyforcancer

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