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Crystal Structure of the Dengue Virus Methyltransferase Bound to a 5′-Capped Octameric RNA
The N-terminal domain of the flavivirus NS5 protein functions as a methyltransferase (MTase). It sequentially methylates the N7 and 2′-O positions of the viral RNA cap structure (GpppA→(7me)GpppA→(7me)GpppA(2′-O-me)). The same NS5 domain could also have a guanylyltransferase activity (GTP+ppA-RNA→Gp...
| Autores principales: | , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2941465/ https://www.ncbi.nlm.nih.gov/pubmed/20862256 http://dx.doi.org/10.1371/journal.pone.0012836 |