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Gender-Related Survival Differences Associated With Polymorphic Variants of Estrogen Receptor Beta (ERβ) in Patients with Metastatic Colon Cancer

Estrogen replacement therapy in women has demonstrated a protective effect in the development of colonic carcinomas. Gender-related differences in the development of colonic carcinomas have also been reported. Estrogen receptor beta (ERβ) is expressed in colon carcinomas and has demonstrated prognos...

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Autores principales: Press, Oliver A., Zhang, Wu, Gordon, Michael A., Yang, Dongyun, Haiman, Christopher A., Azuma, Mizutomo, Iqbal, Syma, Lenz, Heinz-Josef
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2941547/
https://www.ncbi.nlm.nih.gov/pubmed/20548329
http://dx.doi.org/10.1038/tpj.2010.45
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author Press, Oliver A.
Zhang, Wu
Gordon, Michael A.
Yang, Dongyun
Haiman, Christopher A.
Azuma, Mizutomo
Iqbal, Syma
Lenz, Heinz-Josef
author_facet Press, Oliver A.
Zhang, Wu
Gordon, Michael A.
Yang, Dongyun
Haiman, Christopher A.
Azuma, Mizutomo
Iqbal, Syma
Lenz, Heinz-Josef
author_sort Press, Oliver A.
collection PubMed
description Estrogen replacement therapy in women has demonstrated a protective effect in the development of colonic carcinomas. Gender-related differences in the development of colonic carcinomas have also been reported. Estrogen receptor beta (ERβ) is expressed in colon carcinomas and has demonstrated prognostic value in colon cancer patients. This study investigated an ERβ 3’ non-coding polymorphism associated with transcriptional activity to determine clinical outcome in patients with metastatic colon cancer. Genomic DNA from 318 metastatic colon cancer patients, 177 males and 141 females, were collected from 1992 to 2003. These patients were analyzed for CA repeat polymorphism of the ERβ gene. Gender-related survival differences were associated with an ERβ (CA)(n) repeat polymorphism (P for interaction=0.003, the likelihood ratio test). Female patients with any short <22 (CA)(n) repeat alleles had shorter overall survival compared to female patients that had both long ≥22 (CA)(n) repeat alleles. In the male patients the opposite overall survival difference was found. This study supports the role of an ERβ (CA)(n) repeat polymorphism as a prognostic marker in metastatic colon cancer; however, this prognostic factor had opposite implications based on gender.
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spelling pubmed-29415472012-04-01 Gender-Related Survival Differences Associated With Polymorphic Variants of Estrogen Receptor Beta (ERβ) in Patients with Metastatic Colon Cancer Press, Oliver A. Zhang, Wu Gordon, Michael A. Yang, Dongyun Haiman, Christopher A. Azuma, Mizutomo Iqbal, Syma Lenz, Heinz-Josef Pharmacogenomics J Article Estrogen replacement therapy in women has demonstrated a protective effect in the development of colonic carcinomas. Gender-related differences in the development of colonic carcinomas have also been reported. Estrogen receptor beta (ERβ) is expressed in colon carcinomas and has demonstrated prognostic value in colon cancer patients. This study investigated an ERβ 3’ non-coding polymorphism associated with transcriptional activity to determine clinical outcome in patients with metastatic colon cancer. Genomic DNA from 318 metastatic colon cancer patients, 177 males and 141 females, were collected from 1992 to 2003. These patients were analyzed for CA repeat polymorphism of the ERβ gene. Gender-related survival differences were associated with an ERβ (CA)(n) repeat polymorphism (P for interaction=0.003, the likelihood ratio test). Female patients with any short <22 (CA)(n) repeat alleles had shorter overall survival compared to female patients that had both long ≥22 (CA)(n) repeat alleles. In the male patients the opposite overall survival difference was found. This study supports the role of an ERβ (CA)(n) repeat polymorphism as a prognostic marker in metastatic colon cancer; however, this prognostic factor had opposite implications based on gender. 2010-06-15 2011-10 /pmc/articles/PMC2941547/ /pubmed/20548329 http://dx.doi.org/10.1038/tpj.2010.45 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Press, Oliver A.
Zhang, Wu
Gordon, Michael A.
Yang, Dongyun
Haiman, Christopher A.
Azuma, Mizutomo
Iqbal, Syma
Lenz, Heinz-Josef
Gender-Related Survival Differences Associated With Polymorphic Variants of Estrogen Receptor Beta (ERβ) in Patients with Metastatic Colon Cancer
title Gender-Related Survival Differences Associated With Polymorphic Variants of Estrogen Receptor Beta (ERβ) in Patients with Metastatic Colon Cancer
title_full Gender-Related Survival Differences Associated With Polymorphic Variants of Estrogen Receptor Beta (ERβ) in Patients with Metastatic Colon Cancer
title_fullStr Gender-Related Survival Differences Associated With Polymorphic Variants of Estrogen Receptor Beta (ERβ) in Patients with Metastatic Colon Cancer
title_full_unstemmed Gender-Related Survival Differences Associated With Polymorphic Variants of Estrogen Receptor Beta (ERβ) in Patients with Metastatic Colon Cancer
title_short Gender-Related Survival Differences Associated With Polymorphic Variants of Estrogen Receptor Beta (ERβ) in Patients with Metastatic Colon Cancer
title_sort gender-related survival differences associated with polymorphic variants of estrogen receptor beta (erβ) in patients with metastatic colon cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2941547/
https://www.ncbi.nlm.nih.gov/pubmed/20548329
http://dx.doi.org/10.1038/tpj.2010.45
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