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Rab protein evolution and the history of the eukaryotic endomembrane system

Spectacular increases in the quantity of sequence data genome have facilitated major advances in eukaryotic comparative genomics. By exploiting homology with classical model organisms, this makes possible predictions of pathways and cellular functions currently impossible to address in intractable o...

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Detalles Bibliográficos
Autores principales: Brighouse, Andrew, Dacks, Joel B., Field, Mark C.
Formato: Texto
Lenguaje:English
Publicado: SP Birkhäuser Verlag Basel 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2943070/
https://www.ncbi.nlm.nih.gov/pubmed/20582450
http://dx.doi.org/10.1007/s00018-010-0436-1
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author Brighouse, Andrew
Dacks, Joel B.
Field, Mark C.
author_facet Brighouse, Andrew
Dacks, Joel B.
Field, Mark C.
author_sort Brighouse, Andrew
collection PubMed
description Spectacular increases in the quantity of sequence data genome have facilitated major advances in eukaryotic comparative genomics. By exploiting homology with classical model organisms, this makes possible predictions of pathways and cellular functions currently impossible to address in intractable organisms. Echoing realization that core metabolic processes were established very early following evolution of life on earth, it is now emerging that many eukaryotic cellular features, including the endomembrane system, are ancient and organized around near-universal principles. Rab proteins are key mediators of vesicle transport and specificity, and via the presence of multiple paralogues, alterations in interaction specificity and modification of pathways, contribute greatly to the evolution of complexity of membrane transport. Understanding system-level contributions of Rab proteins to evolutionary history provides insight into the multiple processes sculpting cellular transport pathways and the exciting challenges that we face in delving further into the origins of membrane trafficking specificity.
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spelling pubmed-29430702010-10-12 Rab protein evolution and the history of the eukaryotic endomembrane system Brighouse, Andrew Dacks, Joel B. Field, Mark C. Cell Mol Life Sci Review Spectacular increases in the quantity of sequence data genome have facilitated major advances in eukaryotic comparative genomics. By exploiting homology with classical model organisms, this makes possible predictions of pathways and cellular functions currently impossible to address in intractable organisms. Echoing realization that core metabolic processes were established very early following evolution of life on earth, it is now emerging that many eukaryotic cellular features, including the endomembrane system, are ancient and organized around near-universal principles. Rab proteins are key mediators of vesicle transport and specificity, and via the presence of multiple paralogues, alterations in interaction specificity and modification of pathways, contribute greatly to the evolution of complexity of membrane transport. Understanding system-level contributions of Rab proteins to evolutionary history provides insight into the multiple processes sculpting cellular transport pathways and the exciting challenges that we face in delving further into the origins of membrane trafficking specificity. SP Birkhäuser Verlag Basel 2010-06-26 2010 /pmc/articles/PMC2943070/ /pubmed/20582450 http://dx.doi.org/10.1007/s00018-010-0436-1 Text en © The Author(s) 2010 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Review
Brighouse, Andrew
Dacks, Joel B.
Field, Mark C.
Rab protein evolution and the history of the eukaryotic endomembrane system
title Rab protein evolution and the history of the eukaryotic endomembrane system
title_full Rab protein evolution and the history of the eukaryotic endomembrane system
title_fullStr Rab protein evolution and the history of the eukaryotic endomembrane system
title_full_unstemmed Rab protein evolution and the history of the eukaryotic endomembrane system
title_short Rab protein evolution and the history of the eukaryotic endomembrane system
title_sort rab protein evolution and the history of the eukaryotic endomembrane system
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2943070/
https://www.ncbi.nlm.nih.gov/pubmed/20582450
http://dx.doi.org/10.1007/s00018-010-0436-1
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