Cytogenetic Instability in Childhood Acute Lymphoblastic Leukemia Survivors

Contemporary anticancer therapies have largely improved the outcome for children with cancer, especially for Acute Lymphoblastic Leukemia (ALL). Actually, between 78% and 85% of patients achieve complete remission and are alive after 5 years of therapy completion. However, as cure rates increase, ne...

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Detalles Bibliográficos
Autores principales: Brassesco, María Sol, Xavier, Danilo Jordão, Camparoto, Marjori Leiva, Montaldi, Ana Paula, de Godoy, Paulo Roberto D'Auria Vieira, Scrideli, Carlos Alberto, Tone, Luiz Gonzaga, Sakamoto-Hojo, Elza Tiemi
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2943089/
https://www.ncbi.nlm.nih.gov/pubmed/20871850
http://dx.doi.org/10.1155/2011/230481
Descripción
Sumario:Contemporary anticancer therapies have largely improved the outcome for children with cancer, especially for Acute Lymphoblastic Leukemia (ALL). Actually, between 78% and 85% of patients achieve complete remission and are alive after 5 years of therapy completion. However, as cure rates increase, new concerns about the late effects of genotoxic treatment emerge, being the risk of developing secondary neoplasias, the most serious life-threatening rising problem. In the present paper, we describe and review the cytogenetic findings in peripheral lymphocytes from ALL survivors, and discuss aspects associated to the occurrence of increased chromosome rearrangements in this growing cohort.

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