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Specifying exposure classification parameters for sensitivity analysis: family breast cancer history
One of the challenges to implementing sensitivity analysis for exposure misclassification is the process of specifying the classification proportions (eg, sensitivity and specificity). The specification of these assignments is guided by three sources of information: estimates from validation studies...
Autores principales: | , , |
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Formato: | Texto |
Lenguaje: | English |
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Dove Medical Press
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2943170/ https://www.ncbi.nlm.nih.gov/pubmed/20865092 |
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author | Jurek, Anne M Lash, Timothy L Maldonado, George |
author_facet | Jurek, Anne M Lash, Timothy L Maldonado, George |
author_sort | Jurek, Anne M |
collection | PubMed |
description | One of the challenges to implementing sensitivity analysis for exposure misclassification is the process of specifying the classification proportions (eg, sensitivity and specificity). The specification of these assignments is guided by three sources of information: estimates from validation studies, expert judgment, and numerical constraints given the data. The purpose of this teaching paper is to describe the process of using validation data and expert judgment to adjust a breast cancer odds ratio for misclassification of family breast cancer history. The parameterization of various point estimates and prior distributions for sensitivity and specificity were guided by external validation data and expert judgment. We used both nonprobabilistic and probabilistic sensitivity analyses to investigate the dependence of the odds ratio estimate on the classification error. With our assumptions, a wider range of odds ratios adjusted for family breast cancer history misclassification resulted than portrayed in the conventional frequentist confidence interval. |
format | Text |
id | pubmed-2943170 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-29431702010-09-23 Specifying exposure classification parameters for sensitivity analysis: family breast cancer history Jurek, Anne M Lash, Timothy L Maldonado, George Clin Epidemiol Methodology One of the challenges to implementing sensitivity analysis for exposure misclassification is the process of specifying the classification proportions (eg, sensitivity and specificity). The specification of these assignments is guided by three sources of information: estimates from validation studies, expert judgment, and numerical constraints given the data. The purpose of this teaching paper is to describe the process of using validation data and expert judgment to adjust a breast cancer odds ratio for misclassification of family breast cancer history. The parameterization of various point estimates and prior distributions for sensitivity and specificity were guided by external validation data and expert judgment. We used both nonprobabilistic and probabilistic sensitivity analyses to investigate the dependence of the odds ratio estimate on the classification error. With our assumptions, a wider range of odds ratios adjusted for family breast cancer history misclassification resulted than portrayed in the conventional frequentist confidence interval. Dove Medical Press 2009-08-09 /pmc/articles/PMC2943170/ /pubmed/20865092 Text en © 2009 Jurek et al, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited. |
spellingShingle | Methodology Jurek, Anne M Lash, Timothy L Maldonado, George Specifying exposure classification parameters for sensitivity analysis: family breast cancer history |
title | Specifying exposure classification parameters for sensitivity analysis: family breast cancer history |
title_full | Specifying exposure classification parameters for sensitivity analysis: family breast cancer history |
title_fullStr | Specifying exposure classification parameters for sensitivity analysis: family breast cancer history |
title_full_unstemmed | Specifying exposure classification parameters for sensitivity analysis: family breast cancer history |
title_short | Specifying exposure classification parameters for sensitivity analysis: family breast cancer history |
title_sort | specifying exposure classification parameters for sensitivity analysis: family breast cancer history |
topic | Methodology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2943170/ https://www.ncbi.nlm.nih.gov/pubmed/20865092 |
work_keys_str_mv | AT jurekannem specifyingexposureclassificationparametersforsensitivityanalysisfamilybreastcancerhistory AT lashtimothyl specifyingexposureclassificationparametersforsensitivityanalysisfamilybreastcancerhistory AT maldonadogeorge specifyingexposureclassificationparametersforsensitivityanalysisfamilybreastcancerhistory |