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Incidence and risk of chondrolysis in Denmark: A nationwide population-based study

BACKGROUND: Chondrolysis is a rare disease with destruction of cartilage of joints. Incidence and risk factors have not been studied in a formal epidemiologic population-based setting. METHODS: We used the Danish National Registry of Patients (NRP) covering all Danish hospitals to identify all cases...

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Autores principales: Christiansen, Christian F, Thygesen, Sandra K, Pedersen, Lars
Formato: Texto
Lenguaje:English
Publicado: Dove Medical Press 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2943176/
https://www.ncbi.nlm.nih.gov/pubmed/20865107
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author Christiansen, Christian F
Thygesen, Sandra K
Pedersen, Lars
author_facet Christiansen, Christian F
Thygesen, Sandra K
Pedersen, Lars
author_sort Christiansen, Christian F
collection PubMed
description BACKGROUND: Chondrolysis is a rare disease with destruction of cartilage of joints. Incidence and risk factors have not been studied in a formal epidemiologic population-based setting. METHODS: We used the Danish National Registry of Patients (NRP) covering all Danish hospitals to identify all cases of chondrolysis from 1994 to 2008. Incidence rates were estimated using the general population as the denominator. For each chondrolysis patient, 10 age-matched population controls were sampled for a case-control analysis. For cases and controls, we ascertained in the NRP history of diabetes, rheumatoid arthritis, orthopedic surgery, including surgery of shoulder and upper arm, injury to shoulder girdle or upper arm, and treatment with pain pump. We determined the prevalence of these risk factors in cases and controls, and computed odds ratios (OR). RESULTS: We identified 43 patients with chondrolysis in the 15-year study period. The incidence rate was 5.5 per 10,000,000 person-years. Diabetes was more prevalent in chondrolysis cases, compared with the 430 controls (OR = 6.7; 95% confidence intervals [CI]: 1.1–39.9). Orthopedic surgery was also associated with an increased risk of chondrolysis (OR = 28.8, 95% CI: 11.0–75.6), while previous injury was not (OR = 0.8; 95% CI: 0.1–5.9). CONCLUSION: Chondrolysis was rarely diagnosed in Denmark. Diabetes and orthopedic surgery may be risk factors.
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spelling pubmed-29431762010-09-23 Incidence and risk of chondrolysis in Denmark: A nationwide population-based study Christiansen, Christian F Thygesen, Sandra K Pedersen, Lars Clin Epidemiol Original Research BACKGROUND: Chondrolysis is a rare disease with destruction of cartilage of joints. Incidence and risk factors have not been studied in a formal epidemiologic population-based setting. METHODS: We used the Danish National Registry of Patients (NRP) covering all Danish hospitals to identify all cases of chondrolysis from 1994 to 2008. Incidence rates were estimated using the general population as the denominator. For each chondrolysis patient, 10 age-matched population controls were sampled for a case-control analysis. For cases and controls, we ascertained in the NRP history of diabetes, rheumatoid arthritis, orthopedic surgery, including surgery of shoulder and upper arm, injury to shoulder girdle or upper arm, and treatment with pain pump. We determined the prevalence of these risk factors in cases and controls, and computed odds ratios (OR). RESULTS: We identified 43 patients with chondrolysis in the 15-year study period. The incidence rate was 5.5 per 10,000,000 person-years. Diabetes was more prevalent in chondrolysis cases, compared with the 430 controls (OR = 6.7; 95% confidence intervals [CI]: 1.1–39.9). Orthopedic surgery was also associated with an increased risk of chondrolysis (OR = 28.8, 95% CI: 11.0–75.6), while previous injury was not (OR = 0.8; 95% CI: 0.1–5.9). CONCLUSION: Chondrolysis was rarely diagnosed in Denmark. Diabetes and orthopedic surgery may be risk factors. Dove Medical Press 2010-08-09 /pmc/articles/PMC2943176/ /pubmed/20865107 Text en © 2010 Christiansen et al, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.
spellingShingle Original Research
Christiansen, Christian F
Thygesen, Sandra K
Pedersen, Lars
Incidence and risk of chondrolysis in Denmark: A nationwide population-based study
title Incidence and risk of chondrolysis in Denmark: A nationwide population-based study
title_full Incidence and risk of chondrolysis in Denmark: A nationwide population-based study
title_fullStr Incidence and risk of chondrolysis in Denmark: A nationwide population-based study
title_full_unstemmed Incidence and risk of chondrolysis in Denmark: A nationwide population-based study
title_short Incidence and risk of chondrolysis in Denmark: A nationwide population-based study
title_sort incidence and risk of chondrolysis in denmark: a nationwide population-based study
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2943176/
https://www.ncbi.nlm.nih.gov/pubmed/20865107
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