Evaluation of Histone Deacetylases as Drug Targets in Huntington’s Disease models: Study of HDACs in brain tissues from R6/2 and CAG140 knock-in HD mouse models and human patients and in a neuronal HD cell model.

The family of histone deacetylases (HDACs) has recently emerged as important drug targets for treatment of slow progressive neurodegenerative disorders, including Huntington’s disease (HD). Broad pharmaceutical inhibition of HDACs has shown neuroprotective effects in various HD models. Here we exami...

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Detalles Bibliográficos
Autores principales: Quinti, Luisa, Chopra, Vanita, Rotili, Dante, Valente, Sergio, Amore, Allison, Franci, Gianluigi, Meade, Sarah, Valenza, Marta, Altucci, Lucia, Maxwell, Michele M., Cattaneo, Elena, Hersch, Steven, Mai, Antonello, Kazantsev, Aleksey
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Huntington Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2943247/
https://www.ncbi.nlm.nih.gov/pubmed/20877454
http://dx.doi.org/10.1371/currents.RRN1172

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