Crystallographic Studies of Prion Protein (PrP) Segments Suggest How Structural Changes Encoded by Polymorphism at Residue 129 Modulate Susceptibility to Human Prion Disease

A single nucleotide polymorphism (SNP) in codon 129 of the human prion gene, leading to a change from methionine to valine at residue 129 of prion protein (PrP), has been shown to be a determinant in the susceptibility to prion disease. However, the molecular basis of this effect remains unexplained...

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Detalles Bibliográficos
Autores principales: Apostol, Marcin I., Sawaya, Michael R., Cascio, Duilio, Eisenberg, David
Formato: Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2010
Materias:
Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2943325/
https://www.ncbi.nlm.nih.gov/pubmed/20685658
http://dx.doi.org/10.1074/jbc.C110.158303

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2943325/
https://www.ncbi.nlm.nih.gov/pubmed/20685658
http://dx.doi.org/10.1074/jbc.C110.158303

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