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Broca's Region: Novel Organizational Principles and Multiple Receptor Mapping

There is a considerable contrast between the various functions assigned to Broca's region and its relatively simple subdivision into two cytoarchitectonic areas (44 and 45). Since the regional distribution of transmitter receptors in the cerebral cortex has been proven a powerful indicator of f...

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Autores principales: Amunts, Katrin, Lenzen, Marianne, Friederici, Angela D., Schleicher, Axel, Morosan, Patricia, Palomero-Gallagher, Nicola, Zilles, Karl
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2943440/
https://www.ncbi.nlm.nih.gov/pubmed/20877713
http://dx.doi.org/10.1371/journal.pbio.1000489
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author Amunts, Katrin
Lenzen, Marianne
Friederici, Angela D.
Schleicher, Axel
Morosan, Patricia
Palomero-Gallagher, Nicola
Zilles, Karl
author_facet Amunts, Katrin
Lenzen, Marianne
Friederici, Angela D.
Schleicher, Axel
Morosan, Patricia
Palomero-Gallagher, Nicola
Zilles, Karl
author_sort Amunts, Katrin
collection PubMed
description There is a considerable contrast between the various functions assigned to Broca's region and its relatively simple subdivision into two cytoarchitectonic areas (44 and 45). Since the regional distribution of transmitter receptors in the cerebral cortex has been proven a powerful indicator of functional diversity, the subdivision of Broca's region was analyzed here using a multireceptor approach. The distribution patterns of six receptor types using in vitro receptor autoradiography revealed previously unknown areas: a ventral precentral transitional cortex 6r1, dorsal and ventral areas 44d and 44v, anterior and posterior areas 45a and 45p, and areas op8 and op9 in the frontal operculum. A significant lateralization of receptors was demonstrated with respect to the cholinergic M(2) receptor, particularly in area 44v+d. We propose a new concept of the anterior language region, which elucidates the relation between premotor cortex, prefrontal cortex, and Broca's region. It offers human brain homologues to the recently described subdivision of area 45, and the segregation of the ventral premotor cortex in macaque brains. The results provide a novel structural basis of the organization of language regions in the brain.
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spelling pubmed-29434402010-09-28 Broca's Region: Novel Organizational Principles and Multiple Receptor Mapping Amunts, Katrin Lenzen, Marianne Friederici, Angela D. Schleicher, Axel Morosan, Patricia Palomero-Gallagher, Nicola Zilles, Karl PLoS Biol Research Article There is a considerable contrast between the various functions assigned to Broca's region and its relatively simple subdivision into two cytoarchitectonic areas (44 and 45). Since the regional distribution of transmitter receptors in the cerebral cortex has been proven a powerful indicator of functional diversity, the subdivision of Broca's region was analyzed here using a multireceptor approach. The distribution patterns of six receptor types using in vitro receptor autoradiography revealed previously unknown areas: a ventral precentral transitional cortex 6r1, dorsal and ventral areas 44d and 44v, anterior and posterior areas 45a and 45p, and areas op8 and op9 in the frontal operculum. A significant lateralization of receptors was demonstrated with respect to the cholinergic M(2) receptor, particularly in area 44v+d. We propose a new concept of the anterior language region, which elucidates the relation between premotor cortex, prefrontal cortex, and Broca's region. It offers human brain homologues to the recently described subdivision of area 45, and the segregation of the ventral premotor cortex in macaque brains. The results provide a novel structural basis of the organization of language regions in the brain. Public Library of Science 2010-09-21 /pmc/articles/PMC2943440/ /pubmed/20877713 http://dx.doi.org/10.1371/journal.pbio.1000489 Text en Amunts et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Amunts, Katrin
Lenzen, Marianne
Friederici, Angela D.
Schleicher, Axel
Morosan, Patricia
Palomero-Gallagher, Nicola
Zilles, Karl
Broca's Region: Novel Organizational Principles and Multiple Receptor Mapping
title Broca's Region: Novel Organizational Principles and Multiple Receptor Mapping
title_full Broca's Region: Novel Organizational Principles and Multiple Receptor Mapping
title_fullStr Broca's Region: Novel Organizational Principles and Multiple Receptor Mapping
title_full_unstemmed Broca's Region: Novel Organizational Principles and Multiple Receptor Mapping
title_short Broca's Region: Novel Organizational Principles and Multiple Receptor Mapping
title_sort broca's region: novel organizational principles and multiple receptor mapping
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2943440/
https://www.ncbi.nlm.nih.gov/pubmed/20877713
http://dx.doi.org/10.1371/journal.pbio.1000489
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