Post-Stroke Inhibition of Induced NADPH Oxidase Type 4 Prevents Oxidative Stress and Neurodegeneration

Ischemic stroke is the second leading cause of death worldwide. Only one moderately effective therapy exists, albeit with contraindications that exclude 90% of the patients. This medical need contrasts with a high failure rate of more than 1,000 pre-clinical drug candidates for stroke therapies. Thu...

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Detalles Bibliográficos
Autores principales: Kleinschnitz, Christoph, Grund, Henrike, Wingler, Kirstin, Armitage, Melanie E., Jones, Emma, Mittal, Manish, Barit, David, Schwarz, Tobias, Geis, Christian, Kraft, Peter, Barthel, Konstanze, Schuhmann, Michael K., Herrmann, Alexander M., Meuth, Sven G., Stoll, Guido, Meurer, Sabine, Schrewe, Anja, Becker, Lore, Gailus-Durner, Valérie, Fuchs, Helmut, Klopstock, Thomas, de Angelis, Martin Hrabé, Jandeleit-Dahm, Karin, Shah, Ajay M., Weissmann, Norbert, Schmidt, Harald H. H. W.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2943442/
https://www.ncbi.nlm.nih.gov/pubmed/20877715
http://dx.doi.org/10.1371/journal.pbio.1000479

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