Safety and Immunogenicity Study of Multiclade HIV-1 Adenoviral Vector Vaccine Alone or as Boost following a Multiclade HIV-1 DNA Vaccine in Africa

BACKGROUND: We conducted a double-blind, randomized, placebo-controlled Phase I study of a recombinant replication-defective adenovirus type 5 (rAd5) vector expressing HIV-1 Gag and Pol from subtype B and Env from subtypes A, B and C, given alone or as boost following a DNA plasmid vaccine expressin...

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Detalles Bibliográficos
Autores principales: Jaoko, Walter, Karita, Etienne, Kayitenkore, Kayitesi, Omosa-Manyonyi, Gloria, Allen, Susan, Than, Soe, Adams, Elizabeth M., Graham, Barney S., Koup, Richard A., Bailer, Robert T., Smith, Carol, Dally, Len, Farah, Bashir, Anzala, Omu, Muvunyi, Claude M., Bizimana, Jean, Tarragona-Fiol, Tony, Bergin, Philip J., Hayes, Peter, Ho, Martin, Loughran, Kelley, Komaroff, Wendy, Stevens, Gwynneth, Thomson, Helen, Boaz, Mark J., Cox, Josephine H., Schmidt, Claudia, Gilmour, Jill, Nabel, Gary J., Fast, Patricia, Bwayo, Job
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2943475/
https://www.ncbi.nlm.nih.gov/pubmed/20877623
http://dx.doi.org/10.1371/journal.pone.0012873

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