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Development of an online p38α mitogen-activated protein kinase binding assay and integration of LC–HR-MS
A high-resolution screening method was developed for the p38α mitogen-activated protein kinase to detect and identify small-molecule binders. Its central role in inflammatory diseases makes this enzyme a very important drug target. The setup integrates separation by high-performance liquid chromatog...
| Autores principales: | , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Springer-Verlag
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2943585/ https://www.ncbi.nlm.nih.gov/pubmed/20730527 http://dx.doi.org/10.1007/s00216-010-4087-8 |