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The Interleukin 6 −174 C/C Genotype Predicts Greater Rhinovirus Illness
Background. In adults and children with respiratory syncytial virus (RSV) infection, a polymorphism in the interleukin 6 (IL-6) promoter at position −174 predicts illness magnitude. In addition, polymorphisms in the interleukin 10 (IL-10), tumor necrosis factor α (TNF-α), and interferon γ (IFN-γ) ge...
Autores principales: | , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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The University of Chicago Press
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2943745/ https://www.ncbi.nlm.nih.gov/pubmed/20001857 http://dx.doi.org/10.1086/649559 |
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author | Doyle, William J. Casselbrant, Margaretha L. Li-Korotky, Ha-Sheng Cullen Doyle, Allison P. Lo, Chia-Yee Turner, Ronald Cohen, Sheldon |
author_facet | Doyle, William J. Casselbrant, Margaretha L. Li-Korotky, Ha-Sheng Cullen Doyle, Allison P. Lo, Chia-Yee Turner, Ronald Cohen, Sheldon |
author_sort | Doyle, William J. |
collection | PubMed |
description | Background. In adults and children with respiratory syncytial virus (RSV) infection, a polymorphism in the interleukin 6 (IL-6) promoter at position −174 predicts illness magnitude. In addition, polymorphisms in the interleukin 10 (IL-10), tumor necrosis factor α (TNF-α), and interferon γ (IFN-γ) genes are associated with immune responsiveness and the frequency of complications. Here, the effect of these polymorphisms on illness and seroconversion during infection with rhinovirus type 39 (RV39) was evaluated. Methods. Seventy-two adults were genotyped for the selected polymorphisms, experimentally exposed to RV39, and followed to track infection, seroconversion, and symptoms and signs of illness. Regression analysis was used to determine whether these polymorphisms predicted seroconversion and illness magnitude in 57 infected subjects. Results. The low-production IL-6 −174 phenotype (C/C genotype) was associated with greater symptom magnitudes, and the IFN-γ phenotype +874 predicted the frequency of seroconversion. No relationship between the IL-10 or TNF-α polymorphisms and any measured outcome was documented. The concentration of IL-6 protein, as measured in nasal wash fluids from subjects, was positively correlated with symptom magnitude, but it was independent of the IL-6 −174 genotypes representing the high- and low-production phenotypes. Conclusions. These results document statistically significant associations between the IL-6 −174 and IFN-gγpolymorphisms and specific responses to experimental RV39 infection. For the IL-6 −174 polymorphism, the results replicate those for experimental RSV infection. |
format | Text |
id | pubmed-2943745 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | The University of Chicago Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-29437452011-01-01 The Interleukin 6 −174 C/C Genotype Predicts Greater Rhinovirus Illness Doyle, William J. Casselbrant, Margaretha L. Li-Korotky, Ha-Sheng Cullen Doyle, Allison P. Lo, Chia-Yee Turner, Ronald Cohen, Sheldon J Infect Dis Major Articles Background. In adults and children with respiratory syncytial virus (RSV) infection, a polymorphism in the interleukin 6 (IL-6) promoter at position −174 predicts illness magnitude. In addition, polymorphisms in the interleukin 10 (IL-10), tumor necrosis factor α (TNF-α), and interferon γ (IFN-γ) genes are associated with immune responsiveness and the frequency of complications. Here, the effect of these polymorphisms on illness and seroconversion during infection with rhinovirus type 39 (RV39) was evaluated. Methods. Seventy-two adults were genotyped for the selected polymorphisms, experimentally exposed to RV39, and followed to track infection, seroconversion, and symptoms and signs of illness. Regression analysis was used to determine whether these polymorphisms predicted seroconversion and illness magnitude in 57 infected subjects. Results. The low-production IL-6 −174 phenotype (C/C genotype) was associated with greater symptom magnitudes, and the IFN-γ phenotype +874 predicted the frequency of seroconversion. No relationship between the IL-10 or TNF-α polymorphisms and any measured outcome was documented. The concentration of IL-6 protein, as measured in nasal wash fluids from subjects, was positively correlated with symptom magnitude, but it was independent of the IL-6 −174 genotypes representing the high- and low-production phenotypes. Conclusions. These results document statistically significant associations between the IL-6 −174 and IFN-gγpolymorphisms and specific responses to experimental RV39 infection. For the IL-6 −174 polymorphism, the results replicate those for experimental RSV infection. The University of Chicago Press 2010-01-15 2010-01-15 /pmc/articles/PMC2943745/ /pubmed/20001857 http://dx.doi.org/10.1086/649559 Text en © 2010 by the Infectious Diseases Society of America This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections. |
spellingShingle | Major Articles Doyle, William J. Casselbrant, Margaretha L. Li-Korotky, Ha-Sheng Cullen Doyle, Allison P. Lo, Chia-Yee Turner, Ronald Cohen, Sheldon The Interleukin 6 −174 C/C Genotype Predicts Greater Rhinovirus Illness |
title | The Interleukin 6 −174 C/C Genotype Predicts Greater Rhinovirus Illness |
title_full | The Interleukin 6 −174 C/C Genotype Predicts Greater Rhinovirus Illness |
title_fullStr | The Interleukin 6 −174 C/C Genotype Predicts Greater Rhinovirus Illness |
title_full_unstemmed | The Interleukin 6 −174 C/C Genotype Predicts Greater Rhinovirus Illness |
title_short | The Interleukin 6 −174 C/C Genotype Predicts Greater Rhinovirus Illness |
title_sort | interleukin 6 −174 c/c genotype predicts greater rhinovirus illness |
topic | Major Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2943745/ https://www.ncbi.nlm.nih.gov/pubmed/20001857 http://dx.doi.org/10.1086/649559 |
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