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Associations of Obesity Measures with Subtypes of Ischemic Stroke in the ARIC Study
BACKGROUND: Associations between obesity and lacunar, nonlacunar thrombotic, and cardioembolic stroke are not firmly established. METHODS: Body mass index (BMI), waist circumference, and waist-to-hip ratio (WHR) were recorded at baseline between 1987 and 1989 in the Atherosclerosis Risk in Communiti...
Autores principales: | , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Japan Epidemiological Association
2010
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2944008/ https://www.ncbi.nlm.nih.gov/pubmed/20595781 http://dx.doi.org/10.2188/jea.JE20090186 |
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author | Yatsuya, Hiroshi Yamagishi, Kazumasa North, Kari E. Brancati, Frederick L. Stevens, June Folsom, Aaron R. |
author_facet | Yatsuya, Hiroshi Yamagishi, Kazumasa North, Kari E. Brancati, Frederick L. Stevens, June Folsom, Aaron R. |
author_sort | Yatsuya, Hiroshi |
collection | PubMed |
description | BACKGROUND: Associations between obesity and lacunar, nonlacunar thrombotic, and cardioembolic stroke are not firmly established. METHODS: Body mass index (BMI), waist circumference, and waist-to-hip ratio (WHR) were recorded at baseline between 1987 and 1989 in the Atherosclerosis Risk in Communities (ARIC) Study for 13 549 black and white adults who were aged from 45 to 64 years and had no history of cardiovascular disease or cancer. The incidence of ischemic stroke subtypes was ascertained from surveillance of hospital records over a median follow-up of 16.9 years. Cox proportional hazards regression analyses adjusted for age, sex, race, education, smoking status and cigarette years, usual ethanol intake, and leisure time sports index were used to estimate hazard ratios (HRs). RESULTS: The ARIC sample at baseline was 43.8% men and 27.3% blacks; mean age was 53.9 years. Mean BMI, waist circumference, and WHR were 27.7 kg/m(2), 96.8 cm, and 0.92, respectively. The associations of lacunar (n = 138), nonlacunar (n = 338), and cardioembolic (n = 122) ischemic stroke incidence with obesity measures were all generally positive and linear. The HRs for the highest versus lowest quintile of the 3 obesity measures ranged from 1.43–2.21 for lacunar stroke, 1.90–2.16 for nonlacunar stroke, and 2.37–2.91 for cardioembolic stroke. CONCLUSIONS: Although different pathophysiological mechanisms may exist, the incidences of lacunar, nonlacunar, and cardioembolic stroke were all significantly positively associated with the degree of obesity, regardless of the measure used. |
format | Text |
id | pubmed-2944008 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Japan Epidemiological Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-29440082011-09-01 Associations of Obesity Measures with Subtypes of Ischemic Stroke in the ARIC Study Yatsuya, Hiroshi Yamagishi, Kazumasa North, Kari E. Brancati, Frederick L. Stevens, June Folsom, Aaron R. J Epidemiol Original Article BACKGROUND: Associations between obesity and lacunar, nonlacunar thrombotic, and cardioembolic stroke are not firmly established. METHODS: Body mass index (BMI), waist circumference, and waist-to-hip ratio (WHR) were recorded at baseline between 1987 and 1989 in the Atherosclerosis Risk in Communities (ARIC) Study for 13 549 black and white adults who were aged from 45 to 64 years and had no history of cardiovascular disease or cancer. The incidence of ischemic stroke subtypes was ascertained from surveillance of hospital records over a median follow-up of 16.9 years. Cox proportional hazards regression analyses adjusted for age, sex, race, education, smoking status and cigarette years, usual ethanol intake, and leisure time sports index were used to estimate hazard ratios (HRs). RESULTS: The ARIC sample at baseline was 43.8% men and 27.3% blacks; mean age was 53.9 years. Mean BMI, waist circumference, and WHR were 27.7 kg/m(2), 96.8 cm, and 0.92, respectively. The associations of lacunar (n = 138), nonlacunar (n = 338), and cardioembolic (n = 122) ischemic stroke incidence with obesity measures were all generally positive and linear. The HRs for the highest versus lowest quintile of the 3 obesity measures ranged from 1.43–2.21 for lacunar stroke, 1.90–2.16 for nonlacunar stroke, and 2.37–2.91 for cardioembolic stroke. CONCLUSIONS: Although different pathophysiological mechanisms may exist, the incidences of lacunar, nonlacunar, and cardioembolic stroke were all significantly positively associated with the degree of obesity, regardless of the measure used. Japan Epidemiological Association 2010-09-05 /pmc/articles/PMC2944008/ /pubmed/20595781 http://dx.doi.org/10.2188/jea.JE20090186 Text en © 2010 Japan Epidemiological Association. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Original Article Yatsuya, Hiroshi Yamagishi, Kazumasa North, Kari E. Brancati, Frederick L. Stevens, June Folsom, Aaron R. Associations of Obesity Measures with Subtypes of Ischemic Stroke in the ARIC Study |
title | Associations of Obesity Measures with Subtypes of Ischemic Stroke in the ARIC Study |
title_full | Associations of Obesity Measures with Subtypes of Ischemic Stroke in the ARIC Study |
title_fullStr | Associations of Obesity Measures with Subtypes of Ischemic Stroke in the ARIC Study |
title_full_unstemmed | Associations of Obesity Measures with Subtypes of Ischemic Stroke in the ARIC Study |
title_short | Associations of Obesity Measures with Subtypes of Ischemic Stroke in the ARIC Study |
title_sort | associations of obesity measures with subtypes of ischemic stroke in the aric study |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2944008/ https://www.ncbi.nlm.nih.gov/pubmed/20595781 http://dx.doi.org/10.2188/jea.JE20090186 |
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