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Dyspnoea and worsening heart failure in patients with acute heart failure: results from the Pre-RELAX-AHF study
AIMS: Although dyspnoea is the most common cause of admission for acute heart failure (AHF), more needs to be known about its clinical course and prognostic significance. METHODS AND RESULTS: The Pre-RELAX-AHF study randomized 232 subjects with AHF to placebo or four doses of relaxin and evaluated e...
Autores principales: | , , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Oxford University Press
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2944016/ https://www.ncbi.nlm.nih.gov/pubmed/20732868 http://dx.doi.org/10.1093/eurjhf/hfq132 |
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author | Metra, Marco Teerlink, John R. Felker, G. Michael Greenberg, Barry H. Filippatos, Gerasimos Ponikowski, Piotr Teichman, Sam L. Unemori, Elaine Voors, Adriaan A. Weatherley, Beth Davison Cotter, Gad |
author_facet | Metra, Marco Teerlink, John R. Felker, G. Michael Greenberg, Barry H. Filippatos, Gerasimos Ponikowski, Piotr Teichman, Sam L. Unemori, Elaine Voors, Adriaan A. Weatherley, Beth Davison Cotter, Gad |
author_sort | Metra, Marco |
collection | PubMed |
description | AIMS: Although dyspnoea is the most common cause of admission for acute heart failure (AHF), more needs to be known about its clinical course and prognostic significance. METHODS AND RESULTS: The Pre-RELAX-AHF study randomized 232 subjects with AHF to placebo or four doses of relaxin and evaluated early (6–24 h Likert scale) and persistent [change in visual analogue scale area under the curve (VAS AUC) through Day 5] dyspnoea relief. Worsening heart failure (WHF) was defined as worsening AHF signs and symptoms requiring additional therapy. Patients were followed until Day 180. Early dyspnoea relief was observed in only 25% of all patients, and VAS AUC at 5 days was 45% over baseline values in all patients (32% placebo; 50% all relaxin-treated patients). Worsening heart failure to Day 5 was observed in 16% of all patients (21% placebo; 14% relaxin). Lack of persistent dyspnoea relief and WHF were associated with a longer length of initial hospital stay and worse 60-day outcomes. CONCLUSION: Dyspnoea relief in patients admitted with AHF is often incomplete, and many may show WHF after the initial stabilization. Both lack of persistent dyspnoea relief and in-hospital WHF predict a longer length of stay and worse outcome. |
format | Text |
id | pubmed-2944016 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-29440162010-09-27 Dyspnoea and worsening heart failure in patients with acute heart failure: results from the Pre-RELAX-AHF study Metra, Marco Teerlink, John R. Felker, G. Michael Greenberg, Barry H. Filippatos, Gerasimos Ponikowski, Piotr Teichman, Sam L. Unemori, Elaine Voors, Adriaan A. Weatherley, Beth Davison Cotter, Gad Eur J Heart Fail Clinical Trial AIMS: Although dyspnoea is the most common cause of admission for acute heart failure (AHF), more needs to be known about its clinical course and prognostic significance. METHODS AND RESULTS: The Pre-RELAX-AHF study randomized 232 subjects with AHF to placebo or four doses of relaxin and evaluated early (6–24 h Likert scale) and persistent [change in visual analogue scale area under the curve (VAS AUC) through Day 5] dyspnoea relief. Worsening heart failure (WHF) was defined as worsening AHF signs and symptoms requiring additional therapy. Patients were followed until Day 180. Early dyspnoea relief was observed in only 25% of all patients, and VAS AUC at 5 days was 45% over baseline values in all patients (32% placebo; 50% all relaxin-treated patients). Worsening heart failure to Day 5 was observed in 16% of all patients (21% placebo; 14% relaxin). Lack of persistent dyspnoea relief and WHF were associated with a longer length of initial hospital stay and worse 60-day outcomes. CONCLUSION: Dyspnoea relief in patients admitted with AHF is often incomplete, and many may show WHF after the initial stabilization. Both lack of persistent dyspnoea relief and in-hospital WHF predict a longer length of stay and worse outcome. Oxford University Press 2010-10 2010-08-22 /pmc/articles/PMC2944016/ /pubmed/20732868 http://dx.doi.org/10.1093/eurjhf/hfq132 Text en Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2010. For permissions please email: journals.permissions@oxfordjournals.org. http://creativecommons.org/licenses/by-nc/2.5/ The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that the original authorship is properly and fully attributed; the Journal, Learned Society and Oxford University Press are attributed as the original place of publication with correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact journals.permissions@oxfordjournals.org |
spellingShingle | Clinical Trial Metra, Marco Teerlink, John R. Felker, G. Michael Greenberg, Barry H. Filippatos, Gerasimos Ponikowski, Piotr Teichman, Sam L. Unemori, Elaine Voors, Adriaan A. Weatherley, Beth Davison Cotter, Gad Dyspnoea and worsening heart failure in patients with acute heart failure: results from the Pre-RELAX-AHF study |
title | Dyspnoea and worsening heart failure in patients with acute heart failure: results from the Pre-RELAX-AHF study |
title_full | Dyspnoea and worsening heart failure in patients with acute heart failure: results from the Pre-RELAX-AHF study |
title_fullStr | Dyspnoea and worsening heart failure in patients with acute heart failure: results from the Pre-RELAX-AHF study |
title_full_unstemmed | Dyspnoea and worsening heart failure in patients with acute heart failure: results from the Pre-RELAX-AHF study |
title_short | Dyspnoea and worsening heart failure in patients with acute heart failure: results from the Pre-RELAX-AHF study |
title_sort | dyspnoea and worsening heart failure in patients with acute heart failure: results from the pre-relax-ahf study |
topic | Clinical Trial |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2944016/ https://www.ncbi.nlm.nih.gov/pubmed/20732868 http://dx.doi.org/10.1093/eurjhf/hfq132 |
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