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Non–Dioxin-Like Polychlorinated Biphenyls and Risk of Endometriosis

BACKGROUND: Endometriosis, a gynecologic disorder affecting 8–10% of reproductive-age women in the United States, is defined as the presence of endometrial tissue outside the uterus and is linked to pelvic pain and infertility. Environmental contaminants, including polychlorinated biphenyls (PCBs),...

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Autores principales: Trabert, Britton, De Roos, Anneclaire J., Schwartz, Stephen M., Peters, Ulrike, Scholes, Delia, Barr, Dana B., Holt, Victoria L.
Formato: Texto
Lenguaje:English
Publicado: National Institute of Environmental Health Sciences 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2944090/
https://www.ncbi.nlm.nih.gov/pubmed/20423815
http://dx.doi.org/10.1289/ehp.0901444
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author Trabert, Britton
De Roos, Anneclaire J.
Schwartz, Stephen M.
Peters, Ulrike
Scholes, Delia
Barr, Dana B.
Holt, Victoria L.
author_facet Trabert, Britton
De Roos, Anneclaire J.
Schwartz, Stephen M.
Peters, Ulrike
Scholes, Delia
Barr, Dana B.
Holt, Victoria L.
author_sort Trabert, Britton
collection PubMed
description BACKGROUND: Endometriosis, a gynecologic disorder affecting 8–10% of reproductive-age women in the United States, is defined as the presence of endometrial tissue outside the uterus and is linked to pelvic pain and infertility. Environmental contaminants, including polychlorinated biphenyls (PCBs), are hypothesized to contribute to endometriosis risk through effects on steroid hormones. OBJECTIVE: We evaluated serum concentrations of certain noncoplanar PCBs, which have no or only weak dioxin-like properties, as risk factors for endometriosis. METHODS: In a case–control study of Group Health enrollees in western Washington State, 20 PCB congeners were measured in serum from surgically confirmed endometriosis cases that were newly diagnosed between 1996 and 2001 (n = 251) and from female controls matched for age and reference year (n = 538). RESULTS: Summed and estrogenic PCB concentrations were not associated with endometriosis risk [summed: odds ratio (OR) = 1.3; 95% confidence interval (CI), 0.8–2.2; estrogenic: OR = 1.1; 95% CI, 0.8–1.4]. Although several congener-specific ORs were statistically above or below the null (PCB 170: third quartile vs. lowest: OR = 0.5; 95% CI, 0.3–0.9; PCB 196: third quartile vs. lowest: OR = 0.4; 95% CI, 0.2–0.7; PCB 201: second vs. lowest: OR = 0.5; 95% CI, 0.3–0.8; third quartile vs. lowest: OR = 0.4; 95% CI, 0.2–0.7), there were no overall consistent patterns of endometriosis risk. CONCLUSIONS: Taken in context with other North American studies, our findings suggest that noncoplanar PCB concentrations consistent within the range of exposure currently observed in western Washington State do not contribute meaningfully to endometriosis risk.
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spelling pubmed-29440902010-10-05 Non–Dioxin-Like Polychlorinated Biphenyls and Risk of Endometriosis Trabert, Britton De Roos, Anneclaire J. Schwartz, Stephen M. Peters, Ulrike Scholes, Delia Barr, Dana B. Holt, Victoria L. Environ Health Perspect Research BACKGROUND: Endometriosis, a gynecologic disorder affecting 8–10% of reproductive-age women in the United States, is defined as the presence of endometrial tissue outside the uterus and is linked to pelvic pain and infertility. Environmental contaminants, including polychlorinated biphenyls (PCBs), are hypothesized to contribute to endometriosis risk through effects on steroid hormones. OBJECTIVE: We evaluated serum concentrations of certain noncoplanar PCBs, which have no or only weak dioxin-like properties, as risk factors for endometriosis. METHODS: In a case–control study of Group Health enrollees in western Washington State, 20 PCB congeners were measured in serum from surgically confirmed endometriosis cases that were newly diagnosed between 1996 and 2001 (n = 251) and from female controls matched for age and reference year (n = 538). RESULTS: Summed and estrogenic PCB concentrations were not associated with endometriosis risk [summed: odds ratio (OR) = 1.3; 95% confidence interval (CI), 0.8–2.2; estrogenic: OR = 1.1; 95% CI, 0.8–1.4]. Although several congener-specific ORs were statistically above or below the null (PCB 170: third quartile vs. lowest: OR = 0.5; 95% CI, 0.3–0.9; PCB 196: third quartile vs. lowest: OR = 0.4; 95% CI, 0.2–0.7; PCB 201: second vs. lowest: OR = 0.5; 95% CI, 0.3–0.8; third quartile vs. lowest: OR = 0.4; 95% CI, 0.2–0.7), there were no overall consistent patterns of endometriosis risk. CONCLUSIONS: Taken in context with other North American studies, our findings suggest that noncoplanar PCB concentrations consistent within the range of exposure currently observed in western Washington State do not contribute meaningfully to endometriosis risk. National Institute of Environmental Health Sciences 2010-09 2010-04-27 /pmc/articles/PMC2944090/ /pubmed/20423815 http://dx.doi.org/10.1289/ehp.0901444 Text en http://creativecommons.org/publicdomain/mark/1.0/ Publication of EHP lies in the public domain and is therefore without copyright. All text from EHP may be reprinted freely. Use of materials published in EHP should be acknowledged (for example, ?Reproduced with permission from Environmental Health Perspectives?); pertinent reference information should be provided for the article from which the material was reproduced. Articles from EHP, especially the News section, may contain photographs or illustrations copyrighted by other commercial organizations or individuals that may not be used without obtaining prior approval from the holder of the copyright.
spellingShingle Research
Trabert, Britton
De Roos, Anneclaire J.
Schwartz, Stephen M.
Peters, Ulrike
Scholes, Delia
Barr, Dana B.
Holt, Victoria L.
Non–Dioxin-Like Polychlorinated Biphenyls and Risk of Endometriosis
title Non–Dioxin-Like Polychlorinated Biphenyls and Risk of Endometriosis
title_full Non–Dioxin-Like Polychlorinated Biphenyls and Risk of Endometriosis
title_fullStr Non–Dioxin-Like Polychlorinated Biphenyls and Risk of Endometriosis
title_full_unstemmed Non–Dioxin-Like Polychlorinated Biphenyls and Risk of Endometriosis
title_short Non–Dioxin-Like Polychlorinated Biphenyls and Risk of Endometriosis
title_sort non–dioxin-like polychlorinated biphenyls and risk of endometriosis
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2944090/
https://www.ncbi.nlm.nih.gov/pubmed/20423815
http://dx.doi.org/10.1289/ehp.0901444
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