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Appropriate cut-off value for follicle-stimulating hormone in azoospermia to predict spermatogenesis
BACKGROUND: This study was undertaken to determine the optimal cut-off value for FSH to predict the presence of spermatogenesis in patients with non-obstructive azoospermia. METHODS: A total of 206 non-obstructive azoospermic men were enrolled in this prospective study. By using receiver operating c...
Autores principales: | , , , |
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2010
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2944172/ https://www.ncbi.nlm.nih.gov/pubmed/20825644 http://dx.doi.org/10.1186/1477-7827-8-108 |
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author | Chen, Shyh-Chyan Hsieh, Ju-Ton Yu, Hong-Jeng Chang, Hong-Chiang |
author_facet | Chen, Shyh-Chyan Hsieh, Ju-Ton Yu, Hong-Jeng Chang, Hong-Chiang |
author_sort | Chen, Shyh-Chyan |
collection | PubMed |
description | BACKGROUND: This study was undertaken to determine the optimal cut-off value for FSH to predict the presence of spermatogenesis in patients with non-obstructive azoospermia. METHODS: A total of 206 non-obstructive azoospermic men were enrolled in this prospective study. By using receiver operating characteristic (ROC) curves, we determined the optimal cut-off value for FSH and evaluated whether the test could adequately predict successful sperm retrieval. RESULTS: There were 108 non-obstructive azoospermic patients who had evidence of spermatogenesis (group A) and achieved success in sperm retrieval. Another 98 non-obstructive azoospermic patients (group B) failed in sperm retrieval. The mean value of serum FSH in group B was significantly higher than in group A (28.03 +/- 14.56 mIU/mL vs 7.94 +/- 4.95 mIU/mL, p < 0.01; respectively). The area under the receiver operating characteristic curves were 0.939 +/- 0.02 and a cut-off value of 19.4 mIU/mL discriminated between group A and B with a sensitivity of 70%. The positive predictive value for failed sperm retrieval (group B) can reach 100%. CONCLUSIONS: Elevated plasma levels of FSH of more than 19.4 mIU/mL could be used as a reliable criterion for a trial of sperm retrieval from testes in artificial reproductive techniques. |
format | Text |
id | pubmed-2944172 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-29441722010-09-24 Appropriate cut-off value for follicle-stimulating hormone in azoospermia to predict spermatogenesis Chen, Shyh-Chyan Hsieh, Ju-Ton Yu, Hong-Jeng Chang, Hong-Chiang Reprod Biol Endocrinol Research BACKGROUND: This study was undertaken to determine the optimal cut-off value for FSH to predict the presence of spermatogenesis in patients with non-obstructive azoospermia. METHODS: A total of 206 non-obstructive azoospermic men were enrolled in this prospective study. By using receiver operating characteristic (ROC) curves, we determined the optimal cut-off value for FSH and evaluated whether the test could adequately predict successful sperm retrieval. RESULTS: There were 108 non-obstructive azoospermic patients who had evidence of spermatogenesis (group A) and achieved success in sperm retrieval. Another 98 non-obstructive azoospermic patients (group B) failed in sperm retrieval. The mean value of serum FSH in group B was significantly higher than in group A (28.03 +/- 14.56 mIU/mL vs 7.94 +/- 4.95 mIU/mL, p < 0.01; respectively). The area under the receiver operating characteristic curves were 0.939 +/- 0.02 and a cut-off value of 19.4 mIU/mL discriminated between group A and B with a sensitivity of 70%. The positive predictive value for failed sperm retrieval (group B) can reach 100%. CONCLUSIONS: Elevated plasma levels of FSH of more than 19.4 mIU/mL could be used as a reliable criterion for a trial of sperm retrieval from testes in artificial reproductive techniques. BioMed Central 2010-09-08 /pmc/articles/PMC2944172/ /pubmed/20825644 http://dx.doi.org/10.1186/1477-7827-8-108 Text en Copyright ©2010 Chen et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Chen, Shyh-Chyan Hsieh, Ju-Ton Yu, Hong-Jeng Chang, Hong-Chiang Appropriate cut-off value for follicle-stimulating hormone in azoospermia to predict spermatogenesis |
title | Appropriate cut-off value for follicle-stimulating hormone in azoospermia to predict spermatogenesis |
title_full | Appropriate cut-off value for follicle-stimulating hormone in azoospermia to predict spermatogenesis |
title_fullStr | Appropriate cut-off value for follicle-stimulating hormone in azoospermia to predict spermatogenesis |
title_full_unstemmed | Appropriate cut-off value for follicle-stimulating hormone in azoospermia to predict spermatogenesis |
title_short | Appropriate cut-off value for follicle-stimulating hormone in azoospermia to predict spermatogenesis |
title_sort | appropriate cut-off value for follicle-stimulating hormone in azoospermia to predict spermatogenesis |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2944172/ https://www.ncbi.nlm.nih.gov/pubmed/20825644 http://dx.doi.org/10.1186/1477-7827-8-108 |
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