Expression of RNA interference triggers from an oncolytic herpes simplex virus results in specific silencing in tumour cells in vitro and tumours in vivo

BACKGROUND: Delivery of small interfering RNA (siRNA) to tumours remains a major obstacle for the development of RNA interference (RNAi)-based therapeutics. Following the promising pre-clinical and clinical results with the oncolytic herpes simplex virus (HSV) OncoVEX(GM-CSF), we aimed to express RN...

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Detalles Bibliográficos
Autores principales: Anesti, Anna-Maria, Simpson, Guy R, Price, Toby, Pandha, Hardev S, Coffin, Robert S
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2944180/
https://www.ncbi.nlm.nih.gov/pubmed/20836854
http://dx.doi.org/10.1186/1471-2407-10-486

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