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Convergence between Wnt-β-catenin and EGFR signaling in cancer
Wnt and EGFR signaling play key roles in embryonic development and cell proliferation. It is well documented that dysregulation of these two pathways often leads to tumorigenesis with poor prognosis. However, the possible crosstalk between the two pathways in cancer development is largely unknown. A...
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2010
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2944186/ https://www.ncbi.nlm.nih.gov/pubmed/20828404 http://dx.doi.org/10.1186/1476-4598-9-236 |
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author | Hu, Tianhui Li, Cunxi |
author_facet | Hu, Tianhui Li, Cunxi |
author_sort | Hu, Tianhui |
collection | PubMed |
description | Wnt and EGFR signaling play key roles in embryonic development and cell proliferation. It is well documented that dysregulation of these two pathways often leads to tumorigenesis with poor prognosis. However, the possible crosstalk between the two pathways in cancer development is largely unknown. Although some reports show that EGFR might antagonize Wnt signaling during development in Drosophila, an increasing body of evidence indicates that Wnt and EGFR signaling crosstalk and transactivate one another in development and cancer. This review summarizes recent studies on the crosstalk between Wnt and EGFR signaling in cancers and points out several possible convergence points. Wnt ligands can activate EGFR signaling through their 7-transmembrane domain receptor Frizzled while EGFR can activate β-catenin via receptor tyrosine kinase-PI3K/Akt pathway; EGFR has been shown to form a complex with β-catenin and increase the invasion and metastasis of cancer cells. NKD2, a Wnt antagonist by interacting with Dishevelled, also escorts TGFα-containing exocytic vesicles to the basolateral membrane of polarized epithelial cells. Down-regulation of NKD2 causes Wnt activation and TGFα misdelivery, suggesting its functions in cell homeostasis and prevention of tumorigenesis. |
format | Text |
id | pubmed-2944186 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-29441862010-09-24 Convergence between Wnt-β-catenin and EGFR signaling in cancer Hu, Tianhui Li, Cunxi Mol Cancer Review Wnt and EGFR signaling play key roles in embryonic development and cell proliferation. It is well documented that dysregulation of these two pathways often leads to tumorigenesis with poor prognosis. However, the possible crosstalk between the two pathways in cancer development is largely unknown. Although some reports show that EGFR might antagonize Wnt signaling during development in Drosophila, an increasing body of evidence indicates that Wnt and EGFR signaling crosstalk and transactivate one another in development and cancer. This review summarizes recent studies on the crosstalk between Wnt and EGFR signaling in cancers and points out several possible convergence points. Wnt ligands can activate EGFR signaling through their 7-transmembrane domain receptor Frizzled while EGFR can activate β-catenin via receptor tyrosine kinase-PI3K/Akt pathway; EGFR has been shown to form a complex with β-catenin and increase the invasion and metastasis of cancer cells. NKD2, a Wnt antagonist by interacting with Dishevelled, also escorts TGFα-containing exocytic vesicles to the basolateral membrane of polarized epithelial cells. Down-regulation of NKD2 causes Wnt activation and TGFα misdelivery, suggesting its functions in cell homeostasis and prevention of tumorigenesis. BioMed Central 2010-09-09 /pmc/articles/PMC2944186/ /pubmed/20828404 http://dx.doi.org/10.1186/1476-4598-9-236 Text en Copyright ©2010 Hu and Li; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Hu, Tianhui Li, Cunxi Convergence between Wnt-β-catenin and EGFR signaling in cancer |
title | Convergence between Wnt-β-catenin and EGFR signaling in cancer |
title_full | Convergence between Wnt-β-catenin and EGFR signaling in cancer |
title_fullStr | Convergence between Wnt-β-catenin and EGFR signaling in cancer |
title_full_unstemmed | Convergence between Wnt-β-catenin and EGFR signaling in cancer |
title_short | Convergence between Wnt-β-catenin and EGFR signaling in cancer |
title_sort | convergence between wnt-β-catenin and egfr signaling in cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2944186/ https://www.ncbi.nlm.nih.gov/pubmed/20828404 http://dx.doi.org/10.1186/1476-4598-9-236 |
work_keys_str_mv | AT hutianhui convergencebetweenwntbcateninandegfrsignalingincancer AT licunxi convergencebetweenwntbcateninandegfrsignalingincancer |