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Size Isn't All that Matters: Noticing Differences in Size and Temporal Order

The ability to represent time and size is essential for thought and action. These domains have traditionally been investigated independently. However, the processing of events in time and space is postulated to have considerable anatomical and behavioral overlap. Here we formally tested for associat...

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Autores principales: Wencil, Elaine B., Radoeva, Petya, Chatterjee, Anjan
Formato: Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2944649/
https://www.ncbi.nlm.nih.gov/pubmed/20877428
http://dx.doi.org/10.3389/fnhum.2010.00171
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author Wencil, Elaine B.
Radoeva, Petya
Chatterjee, Anjan
author_facet Wencil, Elaine B.
Radoeva, Petya
Chatterjee, Anjan
author_sort Wencil, Elaine B.
collection PubMed
description The ability to represent time and size is essential for thought and action. These domains have traditionally been investigated independently. However, the processing of events in time and space is postulated to have considerable anatomical and behavioral overlap. Here we formally tested for associations and dissociations of abilities in these domains. We examined patterns of impairments in temporal order and relative size judgments in 40 patients with unilateral brain lesions and 20 age-matched control participants. While brain damage can impair both size and temporal order judgments (TOJ), we did not find evidence for global hemispheric differences. When patients were analyzed individually compared to control subjects, we found double dissociations in performances on both kinds of judgments. Voxel lesion symptom mapping allowed us to investigate shared and unique contributions of brain damage to deficits in judgments noticing differences in temporal order and in spatial extent. We found that size and temporal order estimations have overlapping cortical vulnerabilities within the left inferior frontal gyrus, left superior temporal cortex, and bilateral inferior parietal lobule. However, vulnerability unique to TOJ occurred with damage predominantly in left lateralized regions involving inferior and middle frontal cortex and inferior parietal lobule. Conversely, vulnerability unique to size judgments occurred with damage predominantly in right lateralized regions in the supramarginal gyrus and superior temporal cortex. These data provide evidence for interactions between the processing of spatial extent and temporal order; however, they do not provide evidence for right lateralized systems.
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spelling pubmed-29446492010-09-27 Size Isn't All that Matters: Noticing Differences in Size and Temporal Order Wencil, Elaine B. Radoeva, Petya Chatterjee, Anjan Front Hum Neurosci Neuroscience The ability to represent time and size is essential for thought and action. These domains have traditionally been investigated independently. However, the processing of events in time and space is postulated to have considerable anatomical and behavioral overlap. Here we formally tested for associations and dissociations of abilities in these domains. We examined patterns of impairments in temporal order and relative size judgments in 40 patients with unilateral brain lesions and 20 age-matched control participants. While brain damage can impair both size and temporal order judgments (TOJ), we did not find evidence for global hemispheric differences. When patients were analyzed individually compared to control subjects, we found double dissociations in performances on both kinds of judgments. Voxel lesion symptom mapping allowed us to investigate shared and unique contributions of brain damage to deficits in judgments noticing differences in temporal order and in spatial extent. We found that size and temporal order estimations have overlapping cortical vulnerabilities within the left inferior frontal gyrus, left superior temporal cortex, and bilateral inferior parietal lobule. However, vulnerability unique to TOJ occurred with damage predominantly in left lateralized regions involving inferior and middle frontal cortex and inferior parietal lobule. Conversely, vulnerability unique to size judgments occurred with damage predominantly in right lateralized regions in the supramarginal gyrus and superior temporal cortex. These data provide evidence for interactions between the processing of spatial extent and temporal order; however, they do not provide evidence for right lateralized systems. Frontiers Research Foundation 2010-09-14 /pmc/articles/PMC2944649/ /pubmed/20877428 http://dx.doi.org/10.3389/fnhum.2010.00171 Text en Copyright © 2010 Wencil, Radoeva and Chatterjee. http://www.frontiersin.org/licenseagreement This is an open-access article subject to an exclusive license agreement between the authors and the Frontiers Research Foundation, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are credited.
spellingShingle Neuroscience
Wencil, Elaine B.
Radoeva, Petya
Chatterjee, Anjan
Size Isn't All that Matters: Noticing Differences in Size and Temporal Order
title Size Isn't All that Matters: Noticing Differences in Size and Temporal Order
title_full Size Isn't All that Matters: Noticing Differences in Size and Temporal Order
title_fullStr Size Isn't All that Matters: Noticing Differences in Size and Temporal Order
title_full_unstemmed Size Isn't All that Matters: Noticing Differences in Size and Temporal Order
title_short Size Isn't All that Matters: Noticing Differences in Size and Temporal Order
title_sort size isn't all that matters: noticing differences in size and temporal order
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2944649/
https://www.ncbi.nlm.nih.gov/pubmed/20877428
http://dx.doi.org/10.3389/fnhum.2010.00171
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