Molecular Dynamics Simulations Suggest that Electrostatic Funnel Directs Binding of Tamiflu to Influenza N1 Neuraminidases

Oseltamivir (Tamiflu) is currently the frontline antiviral drug employed to fight the flu virus in infected individuals by inhibiting neuraminidase, a flu protein responsible for the release of newly synthesized virions. However, oseltamivir resistance has become a critical problem due to rapid muta...

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Detalles Bibliográficos
Autores principales: Le, Ly, Lee, Eric H., Hardy, David J., Truong, Thanh N., Schulten, Klaus
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2944783/
https://www.ncbi.nlm.nih.gov/pubmed/20885781
http://dx.doi.org/10.1371/journal.pcbi.1000939

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2944783/
https://www.ncbi.nlm.nih.gov/pubmed/20885781
http://dx.doi.org/10.1371/journal.pcbi.1000939

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